OTX015 (MK-8628), a novel BET inhibitor, displays in vitro and in vivo antitumor effects alone and in combination with conventional therapies in glioblastoma models.

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Title:	OTX015 (MK-8628), a novel BET inhibitor, displays in vitro and in vivo antitumor effects alone and in combination with conventional therapies in glioblastoma models.
Authors:	Berenguer-Daizé C; Aix-Marseille Université, Inserm, CRO2 UMR_S 911, Marseille, 13385, France., Astorgues-Xerri L; Oncology Therapeutic Development, 100 Rue Martre, Clichy, 92110, France., Odore E; Oncology Therapeutic Development, 100 Rue Martre, Clichy, 92110, France.; Department of Radio-Pharmacology, Institut Curie, René Huguenin Hospital, 35 Rue Daily, Saint-Cloud, 92210, France., Cayol M; Aix-Marseille Université, Inserm, CRO2 UMR_S 911, Marseille, 13385, France., Cvitkovic E; Oncology Therapeutic Development, 100 Rue Martre, Clichy, 92110, France.; Oncoethix SA (Now Oncoethix GmbH, a Wholly Owned Subsidiary of Merck Sharp and Dohme Corp.), Weystrasse 20, Lucerne, 6000, Switzerland., Noel K; Oncoethix SA (Now Oncoethix GmbH, a Wholly Owned Subsidiary of Merck Sharp and Dohme Corp.), Weystrasse 20, Lucerne, 6000, Switzerland., Bekradda M; Oncology Therapeutic Development, 100 Rue Martre, Clichy, 92110, France., MacKenzie S; Oncology Therapeutic Development, 100 Rue Martre, Clichy, 92110, France., Rezai K; Department of Radio-Pharmacology, Institut Curie, René Huguenin Hospital, 35 Rue Daily, Saint-Cloud, 92210, France., Lokiec F; Department of Radio-Pharmacology, Institut Curie, René Huguenin Hospital, 35 Rue Daily, Saint-Cloud, 92210, France., Riveiro ME; Oncology Therapeutic Development, 100 Rue Martre, Clichy, 92110, France., Ouafik L; Aix-Marseille Université, Inserm, CRO2 UMR_S 911, Marseille, 13385, France.
Source:	International journal of cancer [Int J Cancer] 2016 Nov 01; Vol. 139 (9), pp. 2047-55. Date of Electronic Publication: 2016 Jul 30.
Publication Type:	Journal Article
Journal Info:	Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE
Database:	MEDLINE Ultimate

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ISSN:	1097-0215
DOI:	10.1002/ijc.30256