Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex.

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Title: Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex.
Authors: Verheij MM; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands, Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, M.Verheij@cns.umcn.nl., Vendruscolo LF; Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, Neurobiology of Addiction Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224., Caffino L; Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy, Collaborative Center of Department of Antidrug Policies, Presidency of the Council of Ministers, 00187 Rome, Italy., Giannotti G; Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy, Collaborative Center of Department of Antidrug Policies, Presidency of the Council of Ministers, 00187 Rome, Italy., Cazorla M; University Grenoble Alpes, Grenoble Institute of Neuroscience, GIN F-38000 Grenoble, France, and Institut National de la Santé et de la Recherche Médicale U1216, F-38000 Grenoble, France., Fumagalli F; Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy, Collaborative Center of Department of Antidrug Policies, Presidency of the Council of Ministers, 00187 Rome, Italy., Riva MA; Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy., Homberg JR; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands., Koob GF; Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, Neurobiology of Addiction Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224., Contet C; Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037.
Source: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2016 Aug 03; Vol. 36 (31), pp. 8149-59.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1529-2401
DOI:10.1523/JNEUROSCI.2711-14.2016