Tumour hypoxia causes DNA hypermethylation by reducing TET activity.

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Title: Tumour hypoxia causes DNA hypermethylation by reducing TET activity.
Authors: Thienpont B; Vesalius Research Center, VIB, Leuven, Belgium.; Laboratory of Translational Genetics, Department of Oncology, KU Leuven, Leuven, Belgium., Steinbacher J; Department für Chemie und Pharmazie, Ludwig-Maximilians-Universität, München, Germany., Zhao H; Vesalius Research Center, VIB, Leuven, Belgium.; Laboratory of Translational Genetics, Department of Oncology, KU Leuven, Leuven, Belgium., D'Anna F; Vesalius Research Center, VIB, Leuven, Belgium.; Laboratory of Translational Genetics, Department of Oncology, KU Leuven, Leuven, Belgium., Kuchnio A; Vesalius Research Center, VIB, Leuven, Belgium.; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium., Ploumakis A; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Ghesquière B; Vesalius Research Center, VIB, Leuven, Belgium., Van Dyck L; Vesalius Research Center, VIB, Leuven, Belgium.; Laboratory of Translational Genetics, Department of Oncology, KU Leuven, Leuven, Belgium., Boeckx B; Vesalius Research Center, VIB, Leuven, Belgium.; Laboratory of Translational Genetics, Department of Oncology, KU Leuven, Leuven, Belgium., Schoonjans L; Vesalius Research Center, VIB, Leuven, Belgium.; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium., Hermans E; Gynecologic Oncology, University Hospitals Leuven, Department of Oncology, KU Leuven, Leuven, Belgium., Amant F; Gynecologic Oncology, University Hospitals Leuven, Department of Oncology, KU Leuven, Leuven, Belgium., Kristensen VN; Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway., Peng Koh K; Department of Development and Regeneration, and Stem Cell Institute Leuven, KU Leuven, Leuven, Belgium., Mazzone M; Vesalius Research Center, VIB, Leuven, Belgium.; Laboratory of Molecular Oncology and Angiogenesis, Department of Oncology, KU Leuven, Leuven, Belgium., Coleman M; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Carell T; Department für Chemie und Pharmazie, Ludwig-Maximilians-Universität, München, Germany., Carmeliet P; Vesalius Research Center, VIB, Leuven, Belgium.; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium., Lambrechts D; Vesalius Research Center, VIB, Leuven, Belgium.; Laboratory of Translational Genetics, Department of Oncology, KU Leuven, Leuven, Belgium.
Source: Nature [Nature] 2016 Sep 01; Vol. 537 (7618), pp. 63-68. Date of Electronic Publication: 2016 Aug 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/nature19081