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A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.

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Title: A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.
Authors: Kauppila JHK; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany., Baines HL; Newcastle University LLHW Centre for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Bratic A; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany., Simard ML; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany., Freyer C; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden., Mourier A; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany., Stamp C; Newcastle University LLHW Centre for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Filograna R; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden., Larsson NG; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden. Electronic address: larsson@age.mpg.de., Greaves LC; Newcastle University LLHW Centre for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Stewart JB; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany. Electronic address: jstewart@age.mpg.de.
Source: Cell reports [Cell Rep] 2016 Sep 13; Vol. 16 (11), pp. 2980-2990.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2211-1247
DOI:10.1016/j.celrep.2016.08.037