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A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.

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Title: A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.
Authors: Kauppila JHK; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany., Baines HL; Newcastle University LLHW Centre for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Bratic A; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany., Simard ML; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany., Freyer C; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden., Mourier A; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany., Stamp C; Newcastle University LLHW Centre for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Filograna R; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden., Larsson NG; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden. Electronic address: larsson@age.mpg.de., Greaves LC; Newcastle University LLHW Centre for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Stewart JB; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany. Electronic address: jstewart@age.mpg.de.
Source: Cell reports [Cell Rep] 2016 Sep 13; Vol. 16 (11), pp. 2980-2990.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.
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  Data: <searchLink fieldCode="AU" term="%22Kauppila+JHK%22">Kauppila JHK</searchLink>; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany.<br /><searchLink fieldCode="AU" term="%22Baines+HL%22">Baines HL</searchLink>; Newcastle University LLHW Centre for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.<br /><searchLink fieldCode="AU" term="%22Bratic+A%22">Bratic A</searchLink>; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany.<br /><searchLink fieldCode="AU" term="%22Simard+ML%22">Simard ML</searchLink>; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany.<br /><searchLink fieldCode="AU" term="%22Freyer+C%22">Freyer C</searchLink>; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden.<br /><searchLink fieldCode="AU" term="%22Mourier+A%22">Mourier A</searchLink>; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany.<br /><searchLink fieldCode="AU" term="%22Stamp+C%22">Stamp C</searchLink>; Newcastle University LLHW Centre for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.<br /><searchLink fieldCode="AU" term="%22Filograna+R%22">Filograna R</searchLink>; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden.<br /><searchLink fieldCode="AU" term="%22Larsson+NG%22">Larsson NG</searchLink>; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden. Electronic address: larsson@age.mpg.de.<br /><searchLink fieldCode="AU" term="%22Greaves+LC%22">Greaves LC</searchLink>; Newcastle University LLHW Centre for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.<br /><searchLink fieldCode="AU" term="%22Stewart+JB%22">Stewart JB</searchLink>; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne 50931, Germany. Electronic address: jstewart@age.mpg.de.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2016 Sep 13; Vol. 16 (11), pp. 2980-2990.
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              Text: 2016 Sep 13
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