Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients.

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Title: Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients.
Authors: Rivas JR; Department of Neurology and Neurotherapeutics, UT Southwestern, Dallas, TX, USA., Ireland SJ; Department of Neurology and Neurotherapeutics, UT Southwestern, Dallas, TX, USA., Chkheidze R; Department of Pathology, UT Southwestern, Dallas, TX, USA., Rounds WH; Department of Neurology and Neurotherapeutics, UT Southwestern, Dallas, TX, USA., Lim J; Department of Neurology and Neurotherapeutics, UT Southwestern, Dallas, TX, USA., Johnson J; Department of Neurology and Neurotherapeutics, UT Southwestern, Dallas, TX, USA., Ramirez DM; Department of Neurology and Neurotherapeutics, UT Southwestern, Dallas, TX, USA., Ligocki AJ; Department of Neurology and Neurotherapeutics, UT Southwestern, Dallas, TX, USA., Chen D; Department of Neurology and Neurotherapeutics, UT Southwestern, Dallas, TX, USA., Guzman AA; Department of Neurology and Neurotherapeutics, UT Southwestern, Dallas, TX, USA., Woodhall M; Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Wilson PC; Department of Biomedical Sciences, University of Chicago, Chicago, IL, USA., Meffre E; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., White C 3rd; Department of Pathology, UT Southwestern, Dallas, TX, USA., Greenberg BM; Department of Neurology and Neurotherapeutics, UT Southwestern, Dallas, TX, USA., Waters P; Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Cowell LG; Department of Clinical Science, UT Southwestern, Dallas, TX, USA., Stowe AM; Department of Neurology and Neurotherapeutics, UT Southwestern, Dallas, TX, USA., Monson NL; Department of Neurology and Neurotherapeutics, UT Southwestern, Dallas, TX, USA. Nancy.Monson@UTSouthwestern.edu.; Department of Immunology, UT Southwestern, Dallas, TX, USA. Nancy.Monson@UTSouthwestern.edu.
Source: Acta neuropathologica [Acta Neuropathol] 2017 Jan; Vol. 133 (1), pp. 43-60. Date of Electronic Publication: 2016 Oct 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0533
DOI:10.1007/s00401-016-1627-0