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Structural and conformational determinants of macrocycle cell permeability.

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Title: Structural and conformational determinants of macrocycle cell permeability.
Authors: Over B; Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden., Matsson P; Department of Pharmacy, Uppsala University, Uppsala, Sweden.; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), a node at the Chemical Biology Consortium Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Tyrchan C; Respiratory, Inflammation and Autoimmunity Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden., Artursson P; Department of Pharmacy, Uppsala University, Uppsala, Sweden.; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), a node at the Chemical Biology Consortium Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Doak BC; Department of Chemistry, Uppsala University, Uppsala, Sweden., Foley MA; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA., Hilgendorf C; Drug Safety and Metabolism, Safety &ADME Translational Sciences, AstraZeneca R&D Gothenburg, Mölndal, Sweden., Johnston SE; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA., Lee MD 4th; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA., Lewis RJ; Respiratory, Inflammation and Autoimmunity Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden., McCarren P; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA., Muncipinto G; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA., Norinder U; Swedish Toxicology Sciences Research Center, Södertälje, Sweden., Perry MW; Respiratory, Inflammation and Autoimmunity Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden., Duvall JR; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA., Kihlberg J; Department of Chemistry, Uppsala University, Uppsala, Sweden.
Source: Nature chemical biology [Nat Chem Biol] 2016 Dec; Vol. 12 (12), pp. 1065-1074. Date of Electronic Publication: 2016 Oct 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Over+B%22">Over B</searchLink>; Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Matsson+P%22">Matsson P</searchLink>; Department of Pharmacy, Uppsala University, Uppsala, Sweden.; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), a node at the Chemical Biology Consortium Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Tyrchan+C%22">Tyrchan C</searchLink>; Respiratory, Inflammation and Autoimmunity Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Artursson+P%22">Artursson P</searchLink>; Department of Pharmacy, Uppsala University, Uppsala, Sweden.; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), a node at the Chemical Biology Consortium Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Doak+BC%22">Doak BC</searchLink>; Department of Chemistry, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Foley+MA%22">Foley MA</searchLink>; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Hilgendorf+C%22">Hilgendorf C</searchLink>; Drug Safety and Metabolism, Safety &ADME Translational Sciences, AstraZeneca R&D Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Johnston+SE%22">Johnston SE</searchLink>; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Lee+MD+4th%22">Lee MD 4th</searchLink>; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Lewis+RJ%22">Lewis RJ</searchLink>; Respiratory, Inflammation and Autoimmunity Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22McCarren+P%22">McCarren P</searchLink>; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Muncipinto+G%22">Muncipinto G</searchLink>; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Norinder+U%22">Norinder U</searchLink>; Swedish Toxicology Sciences Research Center, Södertälje, Sweden.<br /><searchLink fieldCode="AU" term="%22Perry+MW%22">Perry MW</searchLink>; Respiratory, Inflammation and Autoimmunity Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Duvall+JR%22">Duvall JR</searchLink>; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kihlberg+J%22">Kihlberg J</searchLink>; Department of Chemistry, Uppsala University, Uppsala, Sweden.
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  Data: <searchLink fieldCode="JN" term="%22101231976%22">Nature chemical biology</searchLink> [Nat Chem Biol] 2016 Dec; Vol. 12 (12), pp. 1065-1074. <i>Date of Electronic Publication: </i>2016 Oct 17.
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