Structural and conformational determinants of macrocycle cell permeability.
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| Title: | Structural and conformational determinants of macrocycle cell permeability. |
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| Authors: | Over B; Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden., Matsson P; Department of Pharmacy, Uppsala University, Uppsala, Sweden.; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), a node at the Chemical Biology Consortium Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Tyrchan C; Respiratory, Inflammation and Autoimmunity Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden., Artursson P; Department of Pharmacy, Uppsala University, Uppsala, Sweden.; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), a node at the Chemical Biology Consortium Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Doak BC; Department of Chemistry, Uppsala University, Uppsala, Sweden., Foley MA; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA., Hilgendorf C; Drug Safety and Metabolism, Safety &ADME Translational Sciences, AstraZeneca R&D Gothenburg, Mölndal, Sweden., Johnston SE; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA., Lee MD 4th; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA., Lewis RJ; Respiratory, Inflammation and Autoimmunity Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden., McCarren P; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA., Muncipinto G; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA., Norinder U; Swedish Toxicology Sciences Research Center, Södertälje, Sweden., Perry MW; Respiratory, Inflammation and Autoimmunity Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden., Duvall JR; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA., Kihlberg J; Department of Chemistry, Uppsala University, Uppsala, Sweden. |
| Source: | Nature chemical biology [Nat Chem Biol] 2016 Dec; Vol. 12 (12), pp. 1065-1074. Date of Electronic Publication: 2016 Oct 17. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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