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A Deep Hydrophobic Binding Cavity is the Main Interaction for Different Y2 R Antagonists.

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Title: A Deep Hydrophobic Binding Cavity is the Main Interaction for Different Y2 R Antagonists.
Authors: Burkert K; Faculty of Biosciences, Pharmacy and Psychology, Leipzig University, Institute of Biochemistry, Brüderstr. 34, 04103, Leipzig, Germany., Zellmann T; Faculty of Biosciences, Pharmacy and Psychology, Leipzig University, Institute of Biochemistry, Brüderstr. 34, 04103, Leipzig, Germany., Meier R; Faculty of Biosciences, Pharmacy and Psychology, Leipzig University, Institute of Biochemistry, Brüderstr. 34, 04103, Leipzig, Germany., Kaiser A; Faculty of Biosciences, Pharmacy and Psychology, Leipzig University, Institute of Biochemistry, Brüderstr. 34, 04103, Leipzig, Germany., Stichel J; Faculty of Biosciences, Pharmacy and Psychology, Leipzig University, Institute of Biochemistry, Brüderstr. 34, 04103, Leipzig, Germany., Meiler J; Center for Structural Biology, Vanderbilt University, 465 21st Avenue South, Nashville, TN, 37203, USA., Mittapalli GK; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Roberts E; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Beck-Sickinger AG; Faculty of Biosciences, Pharmacy and Psychology, Leipzig University, Institute of Biochemistry, Brüderstr. 34, 04103, Leipzig, Germany.
Source: ChemMedChem [ChemMedChem] 2017 Jan 05; Vol. 12 (1), pp. 75-85. Date of Electronic Publication: 2016 Nov 30.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1860-7187
DOI:10.1002/cmdc.201600433