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Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles.

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Title: Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles.
Authors: Gregson JM; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK., Freitag DF; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK., Surendran P; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK., Stitziel NO; 2 Departments of Medicine and Genetics, Washington University School of Medicine, St Louis, USA., Chowdhury R; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK., Burgess S; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK., Kaptoge S; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK., Gao P; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK., Staley JR; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK., Willeit P; 3 Department of Public Health and Primary Care, University of Cambridge, UK.; 4 Department of Neurology, Innsbruck Medical University, Austria., Nielsen SF; 5 Copenhagen University Hospital, University of Copenhagen, Denmark., Caslake M; 6 University of Glasgow, UK., Trompet S; 7 Leiden University Medical Centre, Netherlands., Polfus LM; 8 University of Texas Health Science Center Houston, USA., Kuulasmaa K; 9 THL-National Institute for Health and Welfare, Helsinki, Finland., Kontto J; 9 THL-National Institute for Health and Welfare, Helsinki, Finland., Perola M; 10 Institute of Molecular Medicine FIMM, University of Helsinki, Finland.; 11 Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Blankenberg S; 12 Department of General and Interventional Cardiology, University Heart Centre Hamburg, Germany.; 13 University Medical Centre Hamburg Eppendorf, Hamburg, Germany., Veronesi G; 14 Research Centre, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy., Gianfagna F; 14 Research Centre, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.; 15 Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy., Männistö S; 9 THL-National Institute for Health and Welfare, Helsinki, Finland., Kimura A; 16 Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Japan., Lin H; 17 Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, USA.; 18 The NHLBI's Framingham Heart Study, Framingham, USA., Reilly DF; 19 Merck Research Laboratories, Genetics and Pharmacogenomics, Boston, USA., Gorski M; 20 Department of Genetic Epidemiology, University of Regensburg, Germany.; 21 Department of Nephrology, University Hospital Regensburg, Germany., Mijatovic V; 22 Department of Life and Reproduction Sciences, University of Verona, Italy., Munroe PB; 23 Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK.; 24 NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, UK., Ehret GB; 25 Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.; 26 Cardiology, Department of Medicine, Geneva University Hospital, Switzerland.; 27 Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland., Thompson A; 28 UCB, Brussels, Belgium., Uria-Nickelsen M; 29 Clinical Research, Pfizer Worldwide R&D, Cambridge, USA., Malarstig A; 30 Clinical Research, Pfizer Worldwide R&D, Sollentuna, Sweden., Dehghan A; 31 Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands., Vogt TF; 32 Merck Research Laboratories, Cardiometabolic Disease, Kenilworth, USA.; 33 CHDI Management/CHDI Foundation, Princeton, USA., Sasaoka T; 16 Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Japan., Takeuchi F; 34 Department of Gene Diagnostics and Therapeutics, Research Institute, National Centre for Global Health and Medicine, Tokyo, Japan., Kato N; 34 Department of Gene Diagnostics and Therapeutics, Research Institute, National Centre for Global Health and Medicine, Tokyo, Japan., Yamada Y; 35 Department of Human Functional Genomics, Life Science Research Centre, Mie University, Japan., Kee F; 36 UKCRC Centre of Excellence for Public Health, Queens University, Belfast, Ireland., Müller-Nurasyid M; 37 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany.; 38 Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.; 39 DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.; 40 Department of Medicine I, Ludwig-Maximilians-University Munich, Germany., Ferrières J; 41 Department of Epidemiology, UMR 1027-INSERM, Toulouse University-CHU Toulouse, France., Arveiler D; 42 Department of Epidemiology and Public Health, EA 3430, University of Strasbourg and Strasbourg University Hospital, France., Amouyel P; 43 Department of Epidemiology and Public Health, Institut Pasteur de Lille, France., Salomaa V; 9 THL-National Institute for Health and Welfare, Helsinki, Finland., Boerwinkle E; 44 Human Genetics Center, University of Texas Health Science Center at Houston, USA., Thompson SG; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK., Ford I; 6 University of Glasgow, UK., Wouter Jukema J; 7 Leiden University Medical Centre, Netherlands., Sattar N; 6 University of Glasgow, UK., Packard CJ; 6 University of Glasgow, UK., Shafi Majumder AA; 45 National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh., Alam DS; 46 Centre for Global Health Research, St Michael Hospital, Toronto, Canada., Deloukas P; 47 William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK., Schunkert H; 39 DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.; 48 Deutsches Herzzentrum München, Technische Universität München, Germany., Samani NJ; 49 Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, UK., Kathiresan S; 50 Broad Institute, Cambridge and Massachusetts General Hospital, Boston, USA., Nordestgaard BG; 5 Copenhagen University Hospital, University of Copenhagen, Denmark., Saleheen D; 51 University of Pennsylvania, Philadelphia, USA., Howson JM; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK., Di Angelantonio E; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK., Butterworth AS; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK., Danesh J; 1 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK.; 52 Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.; 53 British Heart Foundation Cambridge Centre of Excellence, University of Cambridge, Cambridge, UK.; 54 National Institute of Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
Corporate Authors: CKDGen consortium, International Consortium for Blood Pressure, CHARGE inflammation working group, MICAD Exome consortium, EPIC-CVD consortium and the CHD Exome+ consortium
Source: European journal of preventive cardiology [Eur J Prev Cardiol] 2017 Mar; Vol. 24 (5), pp. 492-504. Date of Electronic Publication: 2016 Dec 08.
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101564430 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-4881 (Electronic) Linking ISSN: 20474873 NLM ISO Abbreviation: Eur J Prev Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2047-4881
DOI:10.1177/2047487316682186