siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.
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| Title: | siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2. |
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| Authors: | Elkayam E; Keck Structural Biology Lab, Cold Spring Harbor, NY 11724, USA.; Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA.; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Parmar R; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA., Brown CR; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA., Willoughby JL; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA., Theile CS; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA., Manoharan M; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA., Joshua-Tor L; Keck Structural Biology Lab, Cold Spring Harbor, NY 11724, USA.; Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA.; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. |
| Source: | Nucleic acids research [Nucleic Acids Res] 2017 May 05; Vol. 45 (8), pp. 5008. |
| Publication Type: | Journal Article; Published Erratum |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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