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Structural characterization of nonactive site, TrkA-selective kinase inhibitors.

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Title: Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
Authors: Su HP; Global Chemistry, Merck Research Laboratories (MRL), Merck & Co. Inc., West Point, PA 19486; hua-poo_su@merck.com., Rickert K; Screening & Protein Sciences, MRL, Merck & Co. Inc., West Point, PA 19486., Burlein C; In Vitro Pharmacology, MRL, Merck & Co. Inc., West Point, PA 19486., Narayan K; In Vitro Pharmacology, MRL, Merck & Co. Inc., West Point, PA 19486., Bukhtiyarova M; In Vitro Pharmacology, MRL, Merck & Co. Inc., West Point, PA 19486., Hurzy DM; Global Chemistry, Merck Research Laboratories (MRL), Merck & Co. Inc., West Point, PA 19486., Stump CA; Global Chemistry, Merck Research Laboratories (MRL), Merck & Co. Inc., West Point, PA 19486., Zhang X; Global Chemistry, Merck Research Laboratories (MRL), Merck & Co. Inc., West Point, PA 19486., Reid J; Global Chemistry, Merck Research Laboratories (MRL), Merck & Co. Inc., West Point, PA 19486., Krasowska-Zoladek A; Neuroscience Discovery, MRL, Merck & Co. Inc., West Point, PA 19486., Tummala S; Screening & Protein Sciences, MRL, Merck & Co. Inc., West Point, PA 19486., Shipman JM; Screening & Protein Sciences, MRL, Merck & Co. Inc., West Point, PA 19486., Kornienko M; Screening & Protein Sciences, MRL, Merck & Co. Inc., West Point, PA 19486., Lemaire PA; In Vitro Pharmacology, MRL, Merck & Co. Inc., West Point, PA 19486., Krosky D; Screening & Protein Sciences, MRL, Merck & Co. Inc., West Point, PA 19486., Heller A; In Vitro Pharmacology, MRL, Merck & Co. Inc., West Point, PA 19486., Achab A; In Vitro Pharmacology, MRL, Merck & Co. Inc., Boston, MA 02115., Chamberlin C; In Vitro Pharmacology, MRL, Merck & Co. Inc., Boston, MA 02115., Saradjian P; In Vitro Pharmacology, MRL, Merck & Co. Inc., Boston, MA 02115., Sauvagnat B; In Vitro Pharmacology, MRL, Merck & Co. Inc., Boston, MA 02115., Yang X; In Vitro Pharmacology, MRL, Merck & Co. Inc., Boston, MA 02115., Ziebell MR; In Vitro Pharmacology, MRL, Merck & Co. Inc., Boston, MA 02115., Nickbarg E; In Vitro Pharmacology, MRL, Merck & Co. Inc., Boston, MA 02115., Sanders JM; Global Chemistry, Merck Research Laboratories (MRL), Merck & Co. Inc., West Point, PA 19486., Bilodeau MT; Global Chemistry, Merck Research Laboratories (MRL), Merck & Co. Inc., West Point, PA 19486., Carroll SS; In Vitro Pharmacology, MRL, Merck & Co. Inc., West Point, PA 19486., Lumb KJ; Screening & Protein Sciences, MRL, Merck & Co. Inc., West Point, PA 19486., Soisson SM; Global Chemistry, Merck Research Laboratories (MRL), Merck & Co. Inc., West Point, PA 19486., Henze DA; Neuroscience Discovery, MRL, Merck & Co. Inc., West Point, PA 19486., Cooke AJ; Global Chemistry, Merck Research Laboratories (MRL), Merck & Co. Inc., West Point, PA 19486.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Jan 17; Vol. 114 (3), pp. E297-E306. Date of Electronic Publication: 2016 Dec 30.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.1611577114