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Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia.

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Title: Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia.
Authors: Liang K; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA; Stowers Institute for Medical Research, 1000 E. 50th St., Kansas City, MO 64110, USA., Volk AG; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA; Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, 303 E. Superior St., Chicago, IL 60611, USA., Haug JS; Stowers Institute for Medical Research, 1000 E. 50th St., Kansas City, MO 64110, USA., Marshall SA; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA., Woodfin AR; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA., Bartom ET; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA., Gilmore JM; Stowers Institute for Medical Research, 1000 E. 50th St., Kansas City, MO 64110, USA., Florens L; Stowers Institute for Medical Research, 1000 E. 50th St., Kansas City, MO 64110, USA., Washburn MP; Stowers Institute for Medical Research, 1000 E. 50th St., Kansas City, MO 64110, USA; Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS 66150, USA., Sullivan KD; Linda Crnic Institute for Down Syndrome & Department of Pharmacology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Espinosa JM; Linda Crnic Institute for Down Syndrome & Department of Pharmacology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Cannova J; Oncology Institute, Loyola University Chicago, Maywood, IL 60153, USA; Department of Pathology, Loyola University Chicago, Maywood, IL 60153, USA., Zhang J; Oncology Institute, Loyola University Chicago, Maywood, IL 60153, USA; Department of Pathology, Loyola University Chicago, Maywood, IL 60153, USA., Smith ER; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA., Crispino JD; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA; Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, 303 E. Superior St., Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, Il 60611, USA., Shilatifard A; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA; Stowers Institute for Medical Research, 1000 E. 50th St., Kansas City, MO 64110, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, Il 60611, USA. Electronic address: ash@northwestern.edu.
Source: Cell [Cell] 2017 Jan 12; Vol. 168 (1-2), pp. 59-72.e13. Date of Electronic Publication: 2017 Jan 05.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Liang+K%22">Liang K</searchLink>; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA; Stowers Institute for Medical Research, 1000 E. 50th St., Kansas City, MO 64110, USA.<br /><searchLink fieldCode="AU" term="%22Volk+AG%22">Volk AG</searchLink>; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA; Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, 303 E. Superior St., Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Haug+JS%22">Haug JS</searchLink>; Stowers Institute for Medical Research, 1000 E. 50th St., Kansas City, MO 64110, USA.<br /><searchLink fieldCode="AU" term="%22Marshall+SA%22">Marshall SA</searchLink>; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Woodfin+AR%22">Woodfin AR</searchLink>; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Bartom+ET%22">Bartom ET</searchLink>; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Gilmore+JM%22">Gilmore JM</searchLink>; Stowers Institute for Medical Research, 1000 E. 50th St., Kansas City, MO 64110, USA.<br /><searchLink fieldCode="AU" term="%22Florens+L%22">Florens L</searchLink>; Stowers Institute for Medical Research, 1000 E. 50th St., Kansas City, MO 64110, USA.<br /><searchLink fieldCode="AU" term="%22Washburn+MP%22">Washburn MP</searchLink>; Stowers Institute for Medical Research, 1000 E. 50th St., Kansas City, MO 64110, USA; Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS 66150, USA.<br /><searchLink fieldCode="AU" term="%22Sullivan+KD%22">Sullivan KD</searchLink>; Linda Crnic Institute for Down Syndrome & Department of Pharmacology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Espinosa+JM%22">Espinosa JM</searchLink>; Linda Crnic Institute for Down Syndrome & Department of Pharmacology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Cannova+J%22">Cannova J</searchLink>; Oncology Institute, Loyola University Chicago, Maywood, IL 60153, USA; Department of Pathology, Loyola University Chicago, Maywood, IL 60153, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Oncology Institute, Loyola University Chicago, Maywood, IL 60153, USA; Department of Pathology, Loyola University Chicago, Maywood, IL 60153, USA.<br /><searchLink fieldCode="AU" term="%22Smith+ER%22">Smith ER</searchLink>; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Crispino+JD%22">Crispino JD</searchLink>; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA; Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, 303 E. Superior St., Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, Il 60611, USA.<br /><searchLink fieldCode="AU" term="%22Shilatifard+A%22">Shilatifard A</searchLink>; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA; Stowers Institute for Medical Research, 1000 E. 50th St., Kansas City, MO 64110, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, Il 60611, USA. Electronic address: ash@northwestern.edu.
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