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Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.

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Bibliographic Details
Title: Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.
Authors: Huang Y; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhang J; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Yu Z; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhang H; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Wang Y; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Lingel A; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Qi W; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Gu J; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhao K; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Shultz MD; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Wang L; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Fu X; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Sun Y; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhang Q; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Jiang X; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhang J; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhang C; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Li L; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zeng J; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Feng L; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhang C; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Liu Y; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhang M; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhang L; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhao M; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Gao Z; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Liu X; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Fang D; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Guo H; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Mi Y; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Gabriel T; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Dillon MP; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Atadja P; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Oyang C; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
Source: Journal of medicinal chemistry [J Med Chem] 2017 Mar 23; Vol. 60 (6), pp. 2215-2226. Date of Electronic Publication: 2017 Feb 06.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.6b01576