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Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.

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Title: Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.
Authors: Huang Y; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhang J; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Yu Z; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhang H; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Wang Y; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Lingel A; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Qi W; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Gu J; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhao K; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Shultz MD; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Wang L; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Fu X; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Sun Y; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhang Q; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Jiang X; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhang J; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhang C; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Li L; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zeng J; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Feng L; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhang C; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Liu Y; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhang M; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhang L; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Zhao M; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Gao Z; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Liu X; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Fang D; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Guo H; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Mi Y; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Gabriel T; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Dillon MP; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Atadja P; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China., Oyang C; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
Source: Journal of medicinal chemistry [J Med Chem] 2017 Mar 23; Vol. 60 (6), pp. 2215-2226. Date of Electronic Publication: 2017 Feb 06.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.
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  Data: <searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Yu+Z%22">Yu Z</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Lingel+A%22">Lingel A</searchLink>; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Qi+W%22">Qi W</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Gu+J%22">Gu J</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhao+K%22">Zhao K</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Shultz+MD%22">Shultz MD</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Fu+X%22">Fu X</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Jiang+X%22">Jiang X</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zeng+J%22">Zeng J</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Feng+L%22">Feng L</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhao+M%22">Zhao M</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Gao+Z%22">Gao Z</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Fang+D%22">Fang D</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Guo+H%22">Guo H</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Mi+Y%22">Mi Y</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Gabriel+T%22">Gabriel T</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Dillon+MP%22">Dillon MP</searchLink>; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Atadja+P%22">Atadja P</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Oyang+C%22">Oyang C</searchLink>; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2017 Mar 23; Vol. 60 (6), pp. 2215-2226. <i>Date of Electronic Publication: </i>2017 Feb 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.6b01576
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        Text: English
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      – TitleFull: Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.
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