View in EDS

Discovery and evaluation of 1H-pyrrolo[2,3-b]pyridine based selective and reversible small molecule BTK inhibitors for the treatment of rheumatoid arthritis.

Saved in:
Bibliographic Details
Title: Discovery and evaluation of 1H-pyrrolo[2,3-b]pyridine based selective and reversible small molecule BTK inhibitors for the treatment of rheumatoid arthritis.
Authors: Thakkar M; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: mahesh.thakkar@advinus.com., Bhuniya D; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: debnath.bhuniya@advinus.com., Kaduskar R; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: rahul.kaduskar@advinus.com., Mengawade T; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: tanaji.m@advinus.com., Naik K; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: keshav.naik@advinus.com., Salunkhe V; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: videsh.salunkhe@advinus.com., Bhalerao A; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: amit.bhalerao@advinus.com., Kurhade S; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: santosh.kurhade@advinus.com., Mavinahalli J; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: jagadeesh.m@advinus.com., Jain V; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: vaibhav.jain@advinus.com., Petla R; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: rajkanth.petla@advinus.com., Avaragolla S; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: satheesh.a@advinus.com., Ray S; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: swagatam.ray@advinus.com., Rouduri S; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: sreekanth.r@advinus.com., Dhanave A; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: avinash.dhanave@advinus.com., De S; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: siddhartha.de@advinus.com., Pathade V; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: vishal.pathade@advinus.com., Tambe A; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: ashwini.tambe@advinus.com., Raje AA; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: amol.raje@advinus.com., Madgula V; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: vamsi.m@advinus.com., Joshi S; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: sachin.joshi@advinus.com., Nadeem A; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: ahmed.nadeem@advinus.com., Bala M; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: madhu.bala@advinus.com., Umrani D; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: dhananjay.umrani@advinus.com., Hariharan N; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: hariharan.narayanan@advinus.com., Kulkarni B; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: kulkarni.b@advinus.com., Mookhtiar KA; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: kasim.mookhtiar@advinus.com.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Apr 15; Vol. 27 (8), pp. 1867-1873. Date of Electronic Publication: 2017 Feb 22.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 28279528
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Discovery and evaluation of 1H-pyrrolo[2,3-b]pyridine based selective and reversible small molecule BTK inhibitors for the treatment of rheumatoid arthritis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Thakkar+M%22">Thakkar M</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: mahesh.thakkar@advinus.com.<br /><searchLink fieldCode="AU" term="%22Bhuniya+D%22">Bhuniya D</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: debnath.bhuniya@advinus.com.<br /><searchLink fieldCode="AU" term="%22Kaduskar+R%22">Kaduskar R</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: rahul.kaduskar@advinus.com.<br /><searchLink fieldCode="AU" term="%22Mengawade+T%22">Mengawade T</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: tanaji.m@advinus.com.<br /><searchLink fieldCode="AU" term="%22Naik+K%22">Naik K</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: keshav.naik@advinus.com.<br /><searchLink fieldCode="AU" term="%22Salunkhe+V%22">Salunkhe V</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: videsh.salunkhe@advinus.com.<br /><searchLink fieldCode="AU" term="%22Bhalerao+A%22">Bhalerao A</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: amit.bhalerao@advinus.com.<br /><searchLink fieldCode="AU" term="%22Kurhade+S%22">Kurhade S</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: santosh.kurhade@advinus.com.<br /><searchLink fieldCode="AU" term="%22Mavinahalli+J%22">Mavinahalli J</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: jagadeesh.m@advinus.com.<br /><searchLink fieldCode="AU" term="%22Jain+V%22">Jain V</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: vaibhav.jain@advinus.com.<br /><searchLink fieldCode="AU" term="%22Petla+R%22">Petla R</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: rajkanth.petla@advinus.com.<br /><searchLink fieldCode="AU" term="%22Avaragolla+S%22">Avaragolla S</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: satheesh.a@advinus.com.<br /><searchLink fieldCode="AU" term="%22Ray+S%22">Ray S</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: swagatam.ray@advinus.com.<br /><searchLink fieldCode="AU" term="%22Rouduri+S%22">Rouduri S</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: sreekanth.r@advinus.com.<br /><searchLink fieldCode="AU" term="%22Dhanave+A%22">Dhanave A</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: avinash.dhanave@advinus.com.<br /><searchLink fieldCode="AU" term="%22De+S%22">De S</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: siddhartha.de@advinus.com.<br /><searchLink fieldCode="AU" term="%22Pathade+V%22">Pathade V</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: vishal.pathade@advinus.com.<br /><searchLink fieldCode="AU" term="%22Tambe+A%22">Tambe A</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: ashwini.tambe@advinus.com.<br /><searchLink fieldCode="AU" term="%22Raje+AA%22">Raje AA</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: amol.raje@advinus.com.<br /><searchLink fieldCode="AU" term="%22Madgula+V%22">Madgula V</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: vamsi.m@advinus.com.<br /><searchLink fieldCode="AU" term="%22Joshi+S%22">Joshi S</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: sachin.joshi@advinus.com.<br /><searchLink fieldCode="AU" term="%22Nadeem+A%22">Nadeem A</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: ahmed.nadeem@advinus.com.<br /><searchLink fieldCode="AU" term="%22Bala+M%22">Bala M</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: madhu.bala@advinus.com.<br /><searchLink fieldCode="AU" term="%22Umrani+D%22">Umrani D</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: dhananjay.umrani@advinus.com.<br /><searchLink fieldCode="AU" term="%22Hariharan+N%22">Hariharan N</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: hariharan.narayanan@advinus.com.<br /><searchLink fieldCode="AU" term="%22Kulkarni+B%22">Kulkarni B</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: kulkarni.b@advinus.com.<br /><searchLink fieldCode="AU" term="%22Mookhtiar+KA%22">Mookhtiar KA</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd, Plot-9, Phase-I, Rajiv Gandhi InfoTech Park, Hinjewadi, Pune 411057, India. Electronic address: kasim.mookhtiar@advinus.com.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2017 Apr 15; Vol. 27 (8), pp. 1867-1873. <i>Date of Electronic Publication: </i>2017 Feb 22.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107377 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3405 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220960894X%22">0960894X </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem Lett <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=28279528
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.bmcl.2017.02.026
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1867
    Titles:
      – TitleFull: Discovery and evaluation of 1H-pyrrolo[2,3-b]pyridine based selective and reversible small molecule BTK inhibitors for the treatment of rheumatoid arthritis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Thakkar M
      – PersonEntity:
          Name:
            NameFull: Bhuniya D
      – PersonEntity:
          Name:
            NameFull: Kaduskar R
      – PersonEntity:
          Name:
            NameFull: Mengawade T
      – PersonEntity:
          Name:
            NameFull: Naik K
      – PersonEntity:
          Name:
            NameFull: Salunkhe V
      – PersonEntity:
          Name:
            NameFull: Bhalerao A
      – PersonEntity:
          Name:
            NameFull: Kurhade S
      – PersonEntity:
          Name:
            NameFull: Mavinahalli J
      – PersonEntity:
          Name:
            NameFull: Jain V
      – PersonEntity:
          Name:
            NameFull: Petla R
      – PersonEntity:
          Name:
            NameFull: Avaragolla S
      – PersonEntity:
          Name:
            NameFull: Ray S
      – PersonEntity:
          Name:
            NameFull: Rouduri S
      – PersonEntity:
          Name:
            NameFull: Dhanave A
      – PersonEntity:
          Name:
            NameFull: De S
      – PersonEntity:
          Name:
            NameFull: Pathade V
      – PersonEntity:
          Name:
            NameFull: Tambe A
      – PersonEntity:
          Name:
            NameFull: Raje AA
      – PersonEntity:
          Name:
            NameFull: Madgula V
      – PersonEntity:
          Name:
            NameFull: Joshi S
      – PersonEntity:
          Name:
            NameFull: Nadeem A
      – PersonEntity:
          Name:
            NameFull: Bala M
      – PersonEntity:
          Name:
            NameFull: Umrani D
      – PersonEntity:
          Name:
            NameFull: Hariharan N
      – PersonEntity:
          Name:
            NameFull: Kulkarni B
      – PersonEntity:
          Name:
            NameFull: Mookhtiar KA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 04
              Text: 2017 Apr 15
              Type: published
              Y: 2017
          Identifiers:
            – Type: issn-electronic
              Value: 1464-3405
          Numbering:
            – Type: volume
              Value: 27
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Bioorganic & medicinal chemistry letters
              Type: main
ResultId 1