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Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.

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Bibliographic Details
Title: Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.
Authors: Hoyt SB; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States. Electronic address: scott.hoyt@alumni.upenn.edu., Taylor J; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., London C; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Ali A; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Ujjainwalla F; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Tata J; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Struthers M; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Cully D; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Wisniewski T; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Ren N; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Bopp C; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Sok A; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Verras A; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., McMasters D; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Chen Q; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Tung E; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Tang W; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Salituro G; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Clemas J; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Zhou G; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., MacNeil D; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Duffy R; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Xiong Y; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Jun 01; Vol. 27 (11), pp. 2384-2388. Date of Electronic Publication: 2017 Apr 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1464-3405
DOI:10.1016/j.bmcl.2017.04.021