Minipig and Human Metabolism of Aldehyde Oxidase Substrates: In Vitro-In Vivo Comparisons.

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Title: Minipig and Human Metabolism of Aldehyde Oxidase Substrates: In Vitro-In Vivo Comparisons.
Authors: Wilkinson DJ; Department of Metabolism, Covance Laboratories Ltd., Otley Road, Harrogate, North Yorkshire, HG3 1PY, UK. david.wilkinson@covance.com., Southall RL; Department of Metabolism, Covance Laboratories Ltd., Otley Road, Harrogate, North Yorkshire, HG3 1PY, UK., Li M; Department of Drug Metabolism, Covance Laboratories Inc., Madison, Wisconsin, USA., Wright LM; Department of Metabolism, Covance Laboratories Ltd., Otley Road, Harrogate, North Yorkshire, HG3 1PY, UK., Corfield LJ; Department of Metabolism, Covance Laboratories Ltd., Otley Road, Harrogate, North Yorkshire, HG3 1PY, UK., Heeley TA; Department of Metabolism, Covance Laboratories Ltd., Otley Road, Harrogate, North Yorkshire, HG3 1PY, UK., Bratby B; Department of Bioanalysis, Covance Laboratories Ltd., Harrogate, UK., Mannu R; Department of Bioanalysis, Covance Laboratories Ltd., Harrogate, UK., Johnson SL; Department of Metabolism, Covance Laboratories Ltd., Otley Road, Harrogate, North Yorkshire, HG3 1PY, UK., Shaw V; Department of Metabolism, Covance Laboratories Ltd., Otley Road, Harrogate, North Yorkshire, HG3 1PY, UK., Friett HL; Department of Metabolism, Covance Laboratories Ltd., Otley Road, Harrogate, North Yorkshire, HG3 1PY, UK., Blakeburn LA; Department of Metabolism, Covance Laboratories Ltd., Otley Road, Harrogate, North Yorkshire, HG3 1PY, UK., Kendrick JS; Department of Metabolism, Covance Laboratories Ltd., Otley Road, Harrogate, North Yorkshire, HG3 1PY, UK., Otteneder MB; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Source: The AAPS journal [AAPS J] 2017 Jul; Vol. 19 (4), pp. 1163-1174. Date of Electronic Publication: 2017 May 04.
Publication Type: Comparative Study; Journal Article
Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1550-7416
DOI:10.1208/s12248-017-0087-3