IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors.

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Title: IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors.
Authors: Whitehouse G; Division of Transplantation Immunology and Mucosal Biology, Medical Research Council Centre for Transplantation, Faculty of Life Sciences and Medicine, King's College London, London SE5 9RS, United Kingdom.; Institute of Liver Studies, King's College Hospital, London SE5 9RS, United Kingdom., Gray E; Division of Transplantation Immunology and Mucosal Biology, Medical Research Council Centre for Transplantation, Faculty of Life Sciences and Medicine, King's College London, London SE5 9RS, United Kingdom.; Institute of Liver Studies, King's College Hospital, London SE5 9RS, United Kingdom., Mastoridis S; Division of Transplantation Immunology and Mucosal Biology, Medical Research Council Centre for Transplantation, Faculty of Life Sciences and Medicine, King's College London, London SE5 9RS, United Kingdom.; Institute of Liver Studies, King's College Hospital, London SE5 9RS, United Kingdom., Merritt E; Division of Transplantation Immunology and Mucosal Biology, Medical Research Council Centre for Transplantation, Faculty of Life Sciences and Medicine, King's College London, London SE5 9RS, United Kingdom.; Institute of Liver Studies, King's College Hospital, London SE5 9RS, United Kingdom., Kodela E; Division of Transplantation Immunology and Mucosal Biology, Medical Research Council Centre for Transplantation, Faculty of Life Sciences and Medicine, King's College London, London SE5 9RS, United Kingdom.; Institute of Liver Studies, King's College Hospital, London SE5 9RS, United Kingdom., Yang JHM; Department of Immunobiology, Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, United Kingdom., Danger R; Division of Transplantation Immunology and Mucosal Biology, Medical Research Council Centre for Transplantation, Faculty of Life Sciences and Medicine, King's College London, London SE5 9RS, United Kingdom.; Institute of Liver Studies, King's College Hospital, London SE5 9RS, United Kingdom., Mairal M; Division of Transplantation Immunology and Mucosal Biology, Medical Research Council Centre for Transplantation, Faculty of Life Sciences and Medicine, King's College London, London SE5 9RS, United Kingdom.; Institute of Liver Studies, King's College Hospital, London SE5 9RS, United Kingdom., Christakoudi S; Division of Transplantation Immunology and Mucosal Biology, Medical Research Council Centre for Transplantation, Faculty of Life Sciences and Medicine, King's College London, London SE5 9RS, United Kingdom.; Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, United Kingdom., Lozano JJ; Bioinformatics Platform, Biomedical Research Networking Center in Hepatic and Digestive Diseases, Barcelona 08036, Spain., Macdougall IC; Department of Renal Medicine, King's College Hospital, London SE5 9RS, United Kingdom., Tree TIM; Department of Immunobiology, Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, United Kingdom., Sanchez-Fueyo A; Division of Transplantation Immunology and Mucosal Biology, Medical Research Council Centre for Transplantation, Faculty of Life Sciences and Medicine, King's College London, London SE5 9RS, United Kingdom.; Institute of Liver Studies, King's College Hospital, London SE5 9RS, United Kingdom., Martinez-Llordella M; Division of Transplantation Immunology and Mucosal Biology, Medical Research Council Centre for Transplantation, Faculty of Life Sciences and Medicine, King's College London, London SE5 9RS, United Kingdom; marc.martinez-llordella@kcl.ac.uk.; Institute of Liver Studies, King's College Hospital, London SE5 9RS, United Kingdom.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Jul 03; Vol. 114 (27), pp. 7083-7088. Date of Electronic Publication: 2017 Jun 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.1620835114