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Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.

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Title: Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.
Authors: van Esbroeck ACM; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Janssen APA; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Cognetta AB 3rd; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Ogasawara D; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Shpak G; Department of Psychiatry, Erasmus University Medical Centre, 3000 CA, Rotterdam, Netherlands., van der Kroeg M; Department of Psychiatry, Erasmus University Medical Centre, 3000 CA, Rotterdam, Netherlands., Kantae V; Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Baggelaar MP; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., de Vrij FMS; Department of Psychiatry, Erasmus University Medical Centre, 3000 CA, Rotterdam, Netherlands., Deng H; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Allarà M; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche (CNR), Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Italy., Fezza F; Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy., Lin Z; Department of Neuroscience, Erasmus Medical Centre, 3000 CA, Rotterdam, Netherlands., van der Wel T; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Soethoudt M; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Mock ED; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., den Dulk H; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Baak IL; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Florea BI; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Hendriks G; Toxys B.V., Robert Boyleweg 4, 2333 CG, Leiden, Netherlands., De Petrocellis L; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche (CNR), Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Italy., Overkleeft HS; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., Hankemeier T; Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands., De Zeeuw CI; Department of Neuroscience, Erasmus Medical Centre, 3000 CA, Rotterdam, Netherlands.; Netherlands Institute for Neuroscience, Royal Dutch Academy of Arts and Sciences, 1105 BA, Amsterdam, Netherlands., Di Marzo V; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche (CNR), Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Italy., Maccarrone M; European Centre for Brain Research-Institute for Research and Healthcare (IRCCS) Santa Lucia Foundation, Via del Fosso del Fiorano 65, 00143 Rome, Italy.; Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy., Cravatt BF; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Kushner SA; Department of Psychiatry, Erasmus University Medical Centre, 3000 CA, Rotterdam, Netherlands. m.van.der.stelt@chem.leidenuniv.nl s.kushner@erasmusmc.nl., van der Stelt M; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands. m.van.der.stelt@chem.leidenuniv.nl s.kushner@erasmusmc.nl.
Source: Science (New York, N.Y.) [Science] 2017 Jun 09; Vol. 356 (6342), pp. 1084-1087.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.
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  Data: <searchLink fieldCode="AU" term="%22van+Esbroeck+ACM%22">van Esbroeck ACM</searchLink>; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Janssen+APA%22">Janssen APA</searchLink>; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Cognetta+AB+3rd%22">Cognetta AB 3rd</searchLink>; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Ogasawara+D%22">Ogasawara D</searchLink>; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Shpak+G%22">Shpak G</searchLink>; Department of Psychiatry, Erasmus University Medical Centre, 3000 CA, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Kroeg+M%22">van der Kroeg M</searchLink>; Department of Psychiatry, Erasmus University Medical Centre, 3000 CA, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Kantae+V%22">Kantae V</searchLink>; Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Baggelaar+MP%22">Baggelaar MP</searchLink>; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Vrij+FMS%22">de Vrij FMS</searchLink>; Department of Psychiatry, Erasmus University Medical Centre, 3000 CA, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Deng+H%22">Deng H</searchLink>; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Allarà+M%22">Allarà M</searchLink>; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche (CNR), Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Italy.<br /><searchLink fieldCode="AU" term="%22Fezza+F%22">Fezza F</searchLink>; 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Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22De+Zeeuw+CI%22">De Zeeuw CI</searchLink>; Department of Neuroscience, Erasmus Medical Centre, 3000 CA, Rotterdam, Netherlands.; Netherlands Institute for Neuroscience, Royal Dutch Academy of Arts and Sciences, 1105 BA, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Di+Marzo+V%22">Di Marzo V</searchLink>; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche (CNR), Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Italy.<br /><searchLink fieldCode="AU" term="%22Maccarrone+M%22">Maccarrone M</searchLink>; European Centre for Brain Research-Institute for Research and Healthcare (IRCCS) Santa Lucia Foundation, Via del Fosso del Fiorano 65, 00143 Rome, Italy.; Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cravatt+BF%22">Cravatt BF</searchLink>; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Kushner+SA%22">Kushner SA</searchLink>; Department of Psychiatry, Erasmus University Medical Centre, 3000 CA, Rotterdam, Netherlands. m.van.der.stelt@chem.leidenuniv.nl s.kushner@erasmusmc.nl.<br /><searchLink fieldCode="AU" term="%22van+der+Stelt+M%22">van der Stelt M</searchLink>; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, Netherlands. m.van.der.stelt@chem.leidenuniv.nl s.kushner@erasmusmc.nl.
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