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Identification and Profiling of a Selective and Brain Penetrant Radioligand for in Vivo Target Occupancy Measurement of Casein Kinase 1 (CK1) Inhibitors.

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Title: Identification and Profiling of a Selective and Brain Penetrant Radioligand for in Vivo Target Occupancy Measurement of Casein Kinase 1 (CK1) Inhibitors.
Authors: Wager TT; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development , 1 Portland, Cambridge, Massachusetts 02139, United States., Galatsis P; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development , 1 Portland, Cambridge, Massachusetts 02139, United States., Chandrasekaran RY; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development , 1 Portland, Cambridge, Massachusetts 02139, United States.; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development , 558 Eastern Point Rd, Groton, Connecticut 06340, United States., Butler TW; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development , 1 Portland, Cambridge, Massachusetts 02139, United States.; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development , 558 Eastern Point Rd, Groton, Connecticut 06340, United States., Li J; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development , 1 Portland, Cambridge, Massachusetts 02139, United States.; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development , 558 Eastern Point Rd, Groton, Connecticut 06340, United States., Zhang L; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development , 1 Portland, Cambridge, Massachusetts 02139, United States., Mente S; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development , 1 Portland, Cambridge, Massachusetts 02139, United States., Subramanyam C; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development , 1 Portland, Cambridge, Massachusetts 02139, United States.; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development , 558 Eastern Point Rd, Groton, Connecticut 06340, United States., Liu S; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development , 1 Portland, Cambridge, Massachusetts 02139, United States., Doran AC; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development , 558 Eastern Point Rd, Groton, Connecticut 06340, United States., Chang C; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development , 558 Eastern Point Rd, Groton, Connecticut 06340, United States., Fisher K; Internal Medicine Research Unit, Pfizer Worldwide Research and Development , 1 Portland, Cambridge, Massachusetts 02139, United States., Grimwood S; Internal Medicine Research Unit, Pfizer Worldwide Research and Development , 1 Portland, Cambridge, Massachusetts 02139, United States., Hedde JR; Internal Medicine Research Unit, Pfizer Worldwide Research and Development , 1 Portland, Cambridge, Massachusetts 02139, United States., Marconi M; Internal Medicine Research Unit, Pfizer Worldwide Research and Development , 1 Portland, Cambridge, Massachusetts 02139, United States., Schildknegt K; Chemical Research and Development, Pharmaceutical Sciences, Pfizer Worldwide Research and Development , 558 Eastern Point Rd, Groton, Connecticut 06340, United States.
Source: ACS chemical neuroscience [ACS Chem Neurosci] 2017 Sep 20; Vol. 8 (9), pp. 1995-2004. Date of Electronic Publication: 2017 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1948-7193
DOI:10.1021/acschemneuro.7b00155