BACE1 Inhibitor Lanabecestat (AZD3293) in a Phase 1 Study of Healthy Japanese Subjects: Pharmacokinetics and Effects on Plasma and Cerebrospinal Fluid Aβ Peptides.
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| Title: | BACE1 Inhibitor Lanabecestat (AZD3293) in a Phase 1 Study of Healthy Japanese Subjects: Pharmacokinetics and Effects on Plasma and Cerebrospinal Fluid Aβ Peptides. |
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| Authors: | Sakamoto K; Souseikai Fukuoka Mirai Hospital Clinical Research Center, Fukuoka, Japan., Matsuki S; Souseikai Fukuoka Mirai Hospital Clinical Research Center, Fukuoka, Japan., Matsuguma K; Souseikai Fukuoka Mirai Hospital Clinical Research Center, Fukuoka, Japan., Yoshihara T; Souseikai Fukuoka Mirai Hospital Clinical Research Center, Fukuoka, Japan., Uchida N; Clinical Pharmacology, Pharmacology, Showa University School of Medicine, Tokyo, Japan., Azuma F; Research & Development, AstraZeneca KK, Osaka, Japan., Russell M; AstraZeneca, Protein Biomarkers, Personalised Healthcare and Biomarkers, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Alderley Park, UK., Hughes G; AstraZeneca, Protein Biomarkers, Personalised Healthcare and Biomarkers, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Alderley Park, UK., Haeberlein SB; Neuroscience, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Waltham, MA, USA., Alexander RC; Neuroscience, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Waltham, MA, USA., Eketjäll S; Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Huddinge, Sweden., Kugler AR; Neuroscience, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Waltham, MA, USA. |
| Source: | Journal of clinical pharmacology [J Clin Pharmacol] 2017 Nov; Vol. 57 (11), pp. 1460-1471. Date of Electronic Publication: 2017 Jun 15. |
| Publication Type: | Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial |
| Journal Info: | Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1552-4604 |
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| DOI: | 10.1002/jcph.950 |
