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Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates.

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Title: Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates.
Authors: Hinrichs MJM; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland. hinrichsm@medimmune.com., Ryan PM; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland., Zheng B; Clinical Pharmacology and DMPK, MedImmune, Gaithersburg, Maryland., Afif-Rider S; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland., Yu XQ; Clinical Pharmacology and DMPK, MedImmune, Gaithersburg, Maryland., Gunsior M; Clinical Pharmacology and DMPK, MedImmune, Gaithersburg, Maryland., Zhong H; Oncology Research, MedImmune, Gaithersburg, Maryland., Harper J; Oncology Research, MedImmune, Gaithersburg, Maryland., Bezabeh B; Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland., Vashisht K; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland., Rebelatto M; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland., Reed M; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland., Ryan PC; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland., Breen S; Oncology Research, MedImmune, Gaithersburg, Maryland., Patel N; Spirogen Ltd., QMB Innovation Centre, London, United Kingdom., Chen C; Oncology Research, MedImmune, Gaithersburg, Maryland., Masterson L; Spirogen Ltd., QMB Innovation Centre, London, United Kingdom., Tiberghien A; Spirogen Ltd., QMB Innovation Centre, London, United Kingdom., Howard PW; Spirogen Ltd., QMB Innovation Centre, London, United Kingdom., Dimasi N; Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland., Dixit R; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2017 Oct 01; Vol. 23 (19), pp. 5858-5868. Date of Electronic Publication: 2017 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-17-0219