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Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates.

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Title: Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates.
Authors: Hinrichs MJM; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland. hinrichsm@medimmune.com., Ryan PM; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland., Zheng B; Clinical Pharmacology and DMPK, MedImmune, Gaithersburg, Maryland., Afif-Rider S; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland., Yu XQ; Clinical Pharmacology and DMPK, MedImmune, Gaithersburg, Maryland., Gunsior M; Clinical Pharmacology and DMPK, MedImmune, Gaithersburg, Maryland., Zhong H; Oncology Research, MedImmune, Gaithersburg, Maryland., Harper J; Oncology Research, MedImmune, Gaithersburg, Maryland., Bezabeh B; Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland., Vashisht K; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland., Rebelatto M; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland., Reed M; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland., Ryan PC; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland., Breen S; Oncology Research, MedImmune, Gaithersburg, Maryland., Patel N; Spirogen Ltd., QMB Innovation Centre, London, United Kingdom., Chen C; Oncology Research, MedImmune, Gaithersburg, Maryland., Masterson L; Spirogen Ltd., QMB Innovation Centre, London, United Kingdom., Tiberghien A; Spirogen Ltd., QMB Innovation Centre, London, United Kingdom., Howard PW; Spirogen Ltd., QMB Innovation Centre, London, United Kingdom., Dimasi N; Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland., Dixit R; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2017 Oct 01; Vol. 23 (19), pp. 5858-5868. Date of Electronic Publication: 2017 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates.
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  Data: <searchLink fieldCode="AU" term="%22Hinrichs+MJM%22">Hinrichs MJM</searchLink>; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland. hinrichsm@medimmune.com.<br /><searchLink fieldCode="AU" term="%22Ryan+PM%22">Ryan PM</searchLink>; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Zheng+B%22">Zheng B</searchLink>; Clinical Pharmacology and DMPK, MedImmune, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Afif-Rider+S%22">Afif-Rider S</searchLink>; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Yu+XQ%22">Yu XQ</searchLink>; Clinical Pharmacology and DMPK, MedImmune, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Gunsior+M%22">Gunsior M</searchLink>; Clinical Pharmacology and DMPK, MedImmune, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Zhong+H%22">Zhong H</searchLink>; Oncology Research, MedImmune, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Harper+J%22">Harper J</searchLink>; Oncology Research, MedImmune, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Bezabeh+B%22">Bezabeh B</searchLink>; Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Vashisht+K%22">Vashisht K</searchLink>; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Rebelatto+M%22">Rebelatto M</searchLink>; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Reed+M%22">Reed M</searchLink>; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Ryan+PC%22">Ryan PC</searchLink>; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Breen+S%22">Breen S</searchLink>; Oncology Research, MedImmune, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Patel+N%22">Patel N</searchLink>; Spirogen Ltd., QMB Innovation Centre, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Oncology Research, MedImmune, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Masterson+L%22">Masterson L</searchLink>; Spirogen Ltd., QMB Innovation Centre, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tiberghien+A%22">Tiberghien A</searchLink>; Spirogen Ltd., QMB Innovation Centre, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Howard+PW%22">Howard PW</searchLink>; Spirogen Ltd., QMB Innovation Centre, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dimasi+N%22">Dimasi N</searchLink>; Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, Maryland.<br /><searchLink fieldCode="AU" term="%22Dixit+R%22">Dixit R</searchLink>; Biologics Safety Assessment, MedImmune, Gaithersburg, Maryland.
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  Data: <searchLink fieldCode="JN" term="%229502500%22">Clinical cancer research : an official journal of the American Association for Cancer Research</searchLink> [Clin Cancer Res] 2017 Oct 01; Vol. 23 (19), pp. 5858-5868. <i>Date of Electronic Publication: </i>2017 Jun 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502500 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3265 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780432%22">10780432 </searchLink><i>NLM ISO Abbreviation: </i>Clin Cancer Res <i>Subsets: </i>MEDLINE
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