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Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.

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Title: Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.
Authors: Li B; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Orton D; StemSynergy Therapeutics Inc., Miami, FL 33136, USA., Neitzel LR; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Astudillo L; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Shen C; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Long J; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Chen X; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Kirkbride KC; StemSynergy Therapeutics Inc., Miami, FL 33136, USA., Doundoulakis T; StemSynergy Therapeutics Inc., Miami, FL 33136, USA., Guerra ML; StemSynergy Therapeutics Inc., Miami, FL 33136, USA., Zaias J; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Fei DL; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Rodriguez-Blanco J; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Thorne C; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Wang Z; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Jin K; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Nguyen DM; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Sands LR; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Marchetti F; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Abreu MT; Division of Gastroenterology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Cobb MH; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Capobianco AJ; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Lee E; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Robbins DJ; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. drobbins@med.miami.edu.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Source: Science signaling [Sci Signal] 2017 Jun 27; Vol. 10 (485). Date of Electronic Publication: 2017 Jun 27.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
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  Data: Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.
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  Data: <searchLink fieldCode="AU" term="%22Li+B%22">Li B</searchLink>; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Orton+D%22">Orton D</searchLink>; StemSynergy Therapeutics Inc., Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Neitzel+LR%22">Neitzel LR</searchLink>; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Astudillo+L%22">Astudillo L</searchLink>; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Shen+C%22">Shen C</searchLink>; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Long+J%22">Long J</searchLink>; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Kirkbride+KC%22">Kirkbride KC</searchLink>; StemSynergy Therapeutics Inc., Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Doundoulakis+T%22">Doundoulakis T</searchLink>; StemSynergy Therapeutics Inc., Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Guerra+ML%22">Guerra ML</searchLink>; StemSynergy Therapeutics Inc., Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Zaias+J%22">Zaias J</searchLink>; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Fei+DL%22">Fei DL</searchLink>; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Blanco+J%22">Rodriguez-Blanco J</searchLink>; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Thorne+C%22">Thorne C</searchLink>; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Jin+K%22">Jin K</searchLink>; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+DM%22">Nguyen DM</searchLink>; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Sands+LR%22">Sands LR</searchLink>; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Marchetti+F%22">Marchetti F</searchLink>; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Abreu+MT%22">Abreu MT</searchLink>; Division of Gastroenterology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Cobb+MH%22">Cobb MH</searchLink>; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Capobianco+AJ%22">Capobianco AJ</searchLink>; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Lee+E%22">Lee E</searchLink>; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Robbins+DJ%22">Robbins DJ</searchLink>; Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. drobbins@med.miami.edu.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
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