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Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.

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Title: Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.
Authors: Swaminathan S; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Birudukota S; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Thakur MK; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Parveen R; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Kandan S; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Juluri S; Department of Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Shaik S; Department of Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Anand NN; Department of Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Burri RR; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Kristam R; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Hallur MS; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Rajagopal S; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Schreuder H; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany., Langer T; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany., Rudolph C; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany., Ruf S; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany., Dhakshinamoorthy S; Department of Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Gosu R; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India. Electronic address: ramachandraiah_gosu@jubilantbiosys.com., Kannt A; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany; Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2017 Sep 16; Vol. 491 (2), pp. 416-422. Date of Electronic Publication: 2017 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1090-2104
DOI:10.1016/j.bbrc.2017.07.087