Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice.

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Title: Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice.
Authors: Moncsek A; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland., Al-Suraih MS; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN., Trussoni CE; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN., O'Hara SP; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN., Splinter PL; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN., Zuber C; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland., Patsenker E; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland., Valli PV; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland., Fingas CD; Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany., Weber A; Department of Pathology and Molecular Pathology, University Hospital Zürich, Zürich, Switzerland., Zhu Y; The Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN., Tchkonia T; The Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN., Kirkland JL; The Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN., Gores GJ; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN., Müllhaupt B; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland., LaRusso NF; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN., Mertens JC; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.
Source: Hepatology (Baltimore, Md.) [Hepatology] 2018 Jan; Vol. 67 (1), pp. 247-259. Date of Electronic Publication: 2017 Nov 29.
Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1527-3350
DOI:10.1002/hep.29464