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Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice.

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Title: Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice.
Authors: Moncsek A; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland., Al-Suraih MS; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN., Trussoni CE; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN., O'Hara SP; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN., Splinter PL; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN., Zuber C; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland., Patsenker E; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland., Valli PV; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland., Fingas CD; Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany., Weber A; Department of Pathology and Molecular Pathology, University Hospital Zürich, Zürich, Switzerland., Zhu Y; The Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN., Tchkonia T; The Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN., Kirkland JL; The Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN., Gores GJ; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN., Müllhaupt B; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland., LaRusso NF; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN., Mertens JC; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.
Source: Hepatology (Baltimore, Md.) [Hepatology] 2018 Jan; Vol. 67 (1), pp. 247-259. Date of Electronic Publication: 2017 Nov 29.
Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2<superscript>-/-</superscript> ) mice.
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  Data: <searchLink fieldCode="AU" term="%22Moncsek+A%22">Moncsek A</searchLink>; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Al-Suraih+MS%22">Al-Suraih MS</searchLink>; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Trussoni+CE%22">Trussoni CE</searchLink>; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22O'Hara+SP%22">O'Hara SP</searchLink>; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Splinter+PL%22">Splinter PL</searchLink>; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Zuber+C%22">Zuber C</searchLink>; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Patsenker+E%22">Patsenker E</searchLink>; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Valli+PV%22">Valli PV</searchLink>; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fingas+CD%22">Fingas CD</searchLink>; Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Weber+A%22">Weber A</searchLink>; Department of Pathology and Molecular Pathology, University Hospital Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; The Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Tchkonia+T%22">Tchkonia T</searchLink>; The Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Kirkland+JL%22">Kirkland JL</searchLink>; The Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Gores+GJ%22">Gores GJ</searchLink>; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Müllhaupt+B%22">Müllhaupt B</searchLink>; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22LaRusso+NF%22">LaRusso NF</searchLink>; Division of Gastroenterology and Hepatology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Mertens+JC%22">Mertens JC</searchLink>; Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%228302946%22">Hepatology (Baltimore, Md.)</searchLink> [Hepatology] 2018 Jan; Vol. 67 (1), pp. 247-259. <i>Date of Electronic Publication: </i>2017 Nov 29.
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  Data: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wolters+Kluwer+Health%2C+Inc%22">Wolters Kluwer Health, Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8302946 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1527-3350 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202709139%22">02709139 </searchLink><i>NLM ISO Abbreviation: </i>Hepatology <i>Subsets: </i>MEDLINE
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