Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides.

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Title: Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides.
Authors: Iwamoto N; Wave Life Sciences, Cambridge, Massachusetts, USA., Butler DCD; Wave Life Sciences, Cambridge, Massachusetts, USA., Svrzikapa N; Wave Life Sciences, Cambridge, Massachusetts, USA., Mohapatra S; Wave Life Sciences, Cambridge, Massachusetts, USA., Zlatev I; Wave Life Sciences, Cambridge, Massachusetts, USA., Sah DWY; Wave Life Sciences, Cambridge, Massachusetts, USA., Meena; Wave Life Sciences, Cambridge, Massachusetts, USA., Standley SM; Wave Life Sciences, Cambridge, Massachusetts, USA., Lu G; Wave Life Sciences, Cambridge, Massachusetts, USA., Apponi LH; Wave Life Sciences, Cambridge, Massachusetts, USA., Frank-Kamenetsky M; Wave Life Sciences, Cambridge, Massachusetts, USA., Zhang JJ; Wave Life Sciences, Cambridge, Massachusetts, USA., Vargeese C; Wave Life Sciences, Cambridge, Massachusetts, USA., Verdine GL; Wave Life Sciences, Cambridge, Massachusetts, USA.; Department of Stem Cell and Regenerative Biology, Department of Chemistry and Chemical Biology, Harvard University and Harvard Medical School, Cambridge, Massachusetts, USA.
Source: Nature biotechnology [Nat Biotechnol] 2017 Sep; Vol. 35 (9), pp. 845-851. Date of Electronic Publication: 2017 Aug 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-1696
DOI:10.1038/nbt.3948