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A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes.

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Title: A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes.
Authors: Mercader JM; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Barcelona Supercomputing Center, Joint BSC-CRG-IRB Research Programme in Computational Biology, Barcelona, Spain., Liao RG; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Bell AD; Department of Genetics, Harvard Medical School, Boston, MA.; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Dymek Z; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Estrada K; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Tukiainen T; Department of Genetics, Harvard Medical School, Boston, MA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA., Huerta-Chagoya A; Consejo Nacional de Ciencia y Tecnología (CONACYT), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Moreno-Macías H; Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Universidad Autónoma Metropolitana, Mexico City, Mexico., Jablonski KA; The Biostatistics Center, The George Washington University, Rockville, MD., Hanson RL; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ., Walford GA; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Moran I; Department of Medicine, Imperial College London, London, U.K., Chen L; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA., Agarwala V; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Ordoñez-Sánchez ML; Consejo Nacional de Ciencia y Tecnología (CONACYT), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Rodríguez-Guillen R; Consejo Nacional de Ciencia y Tecnología (CONACYT), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Rodríguez-Torres M; Consejo Nacional de Ciencia y Tecnología (CONACYT), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Segura-Kato Y; Consejo Nacional de Ciencia y Tecnología (CONACYT), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., García-Ortiz H; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Centeno-Cruz F; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Barajas-Olmos F; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Caulkins L; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Puppala S; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX., Fontanillas P; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Williams AL; Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY., Bonàs-Guarch S; Barcelona Supercomputing Center, Joint BSC-CRG-IRB Research Programme in Computational Biology, Barcelona, Spain., Hartl C; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Ripke S; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany., Tooley K; Department of Genetics, Harvard Medical School, Boston, MA.; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Lane J; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Zerrweck C; Clínica Integral de Cirugía para la Obesidad y Enfermedades Metabólicas, Hospital General Tláhuac, Mexico City, Mexico., Martínez-Hernández A; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Córdova EJ; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Mendoza-Caamal E; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Contreras-Cubas C; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., González-Villalpando ME; Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Pública, Mexico City, Mexico., Cruz-Bautista I; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Muñoz-Hernández L; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Gómez-Velasco D; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Alvirde U; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Henderson BE; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Wilkens LR; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI., Le Marchand L; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI., Arellano-Campos O; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Riba L; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Harden M; The Genomics Platform, Broad Institute, Cambridge, MA., Gabriel S; The Genomics Platform, Broad Institute, Cambridge, MA., Abboud HE; Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX., Cortes ML; Broad Institute, Cambridge, MA., Revilla-Monsalve C; Unidad de Investigación Médica en Enfermedades Metabólicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Islas-Andrade S; Unidad de Investigación Médica en Enfermedades Metabólicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Soberon X; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Curran JE; South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX., Jenkinson CP; South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX., DeFronzo RA; Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX., Lehman DM; Departments of Medicine and Cellular & Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX., Hanis CL; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX., Bell GI; Department of Medicine, The University of Chicago, Chicago, IL.; Department of Human Genetics, The University of Chicago, Chicago, IL., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI., Blangero J; South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX., Duggirala R; South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX., Saxena R; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA., MacArthur D; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA., Ferrer J; Department of Medicine, Imperial College London, London, U.K.; Genomic Programming of Beta Cells and Diabetes, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.; CIBERDEM, Barcelona, Spain., McCarroll SA; Department of Genetics, Harvard Medical School, Boston, MA.; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., Torrents D; Barcelona Supercomputing Center, Joint BSC-CRG-IRB Research Programme in Computational Biology, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain., Knowler WC; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ., Baier LJ; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ., Burtt N; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA., González-Villalpando C; Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Pública, Mexico City, Mexico., Haiman CA; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI., Aguilar-Salinas CA; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Tusié-Luna T; Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Flannick J; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Molecular Biology, Harvard Medical School, Boston, MA., Jacobs SBR; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA., Orozco L; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Altshuler D; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Genetics, Harvard Medical School, Boston, MA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Molecular Biology, Harvard Medical School, Boston, MA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA., Florez JC; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA jcflorez@mgh.harvard.edu.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.
Corporate Authors: Diabetes Prevention Program Research Group, Broad Genomics Platform, T2D-GENES Consortium, SIGMA T2D Genetics Consortium
Source: Diabetes [Diabetes] 2017 Nov; Vol. 66 (11), pp. 2903-2914. Date of Electronic Publication: 2017 Aug 24.
Publication Type: Journal Article
Journal Info: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
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  Data: A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes.
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  Label: Authors
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Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Tukiainen+T%22">Tukiainen T</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Huerta-Chagoya+A%22">Huerta-Chagoya A</searchLink>; Consejo Nacional de Ciencia y Tecnología (CONACYT), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Moreno-Macías+H%22">Moreno-Macías H</searchLink>; Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Universidad Autónoma Metropolitana, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Jablonski+KA%22">Jablonski KA</searchLink>; The Biostatistics Center, The George Washington University, Rockville, MD.<br /><searchLink fieldCode="AU" term="%22Hanson+RL%22">Hanson RL</searchLink>; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ.<br /><searchLink fieldCode="AU" term="%22Walford+GA%22">Walford GA</searchLink>; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Moran+I%22">Moran I</searchLink>; Department of Medicine, Imperial College London, London, U.K.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Agarwala+V%22">Agarwala V</searchLink>; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Ordoñez-Sánchez+ML%22">Ordoñez-Sánchez ML</searchLink>; Consejo Nacional de Ciencia y Tecnología (CONACYT), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Guillen+R%22">Rodríguez-Guillen R</searchLink>; Consejo Nacional de Ciencia y Tecnología (CONACYT), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Torres+M%22">Rodríguez-Torres M</searchLink>; Consejo Nacional de Ciencia y Tecnología (CONACYT), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Segura-Kato+Y%22">Segura-Kato Y</searchLink>; Consejo Nacional de Ciencia y Tecnología (CONACYT), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22García-Ortiz+H%22">García-Ortiz H</searchLink>; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Centeno-Cruz+F%22">Centeno-Cruz F</searchLink>; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Barajas-Olmos+F%22">Barajas-Olmos F</searchLink>; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Caulkins+L%22">Caulkins L</searchLink>; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Puppala+S%22">Puppala S</searchLink>; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX.<br /><searchLink fieldCode="AU" term="%22Fontanillas+P%22">Fontanillas P</searchLink>; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Williams+AL%22">Williams AL</searchLink>; Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY.<br /><searchLink fieldCode="AU" term="%22Bonàs-Guarch+S%22">Bonàs-Guarch S</searchLink>; Barcelona Supercomputing Center, Joint BSC-CRG-IRB Research Programme in Computational Biology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Hartl+C%22">Hartl C</searchLink>; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Ripke+S%22">Ripke S</searchLink>; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Tooley+K%22">Tooley K</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA.; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Lane+J%22">Lane J</searchLink>; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Zerrweck+C%22">Zerrweck C</searchLink>; Clínica Integral de Cirugía para la Obesidad y Enfermedades Metabólicas, Hospital General Tláhuac, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Martínez-Hernández+A%22">Martínez-Hernández A</searchLink>; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Córdova+EJ%22">Córdova EJ</searchLink>; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Mendoza-Caamal+E%22">Mendoza-Caamal E</searchLink>; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Contreras-Cubas+C%22">Contreras-Cubas C</searchLink>; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22González-Villalpando+ME%22">González-Villalpando ME</searchLink>; Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Pública, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Cruz-Bautista+I%22">Cruz-Bautista I</searchLink>; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Muñoz-Hernández+L%22">Muñoz-Hernández L</searchLink>; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Gómez-Velasco+D%22">Gómez-Velasco D</searchLink>; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Alvirde+U%22">Alvirde U</searchLink>; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Henderson+BE%22">Henderson BE</searchLink>; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Wilkens+LR%22">Wilkens LR</searchLink>; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI.<br /><searchLink fieldCode="AU" term="%22Le+Marchand+L%22">Le Marchand L</searchLink>; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI.<br /><searchLink fieldCode="AU" term="%22Arellano-Campos+O%22">Arellano-Campos O</searchLink>; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Riba+L%22">Riba L</searchLink>; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Harden+M%22">Harden M</searchLink>; The Genomics Platform, Broad Institute, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Gabriel+S%22">Gabriel S</searchLink>; The Genomics Platform, Broad Institute, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Abboud+HE%22">Abboud HE</searchLink>; Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX.<br /><searchLink fieldCode="AU" term="%22Cortes+ML%22">Cortes ML</searchLink>; Broad Institute, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Revilla-Monsalve+C%22">Revilla-Monsalve C</searchLink>; Unidad de Investigación Médica en Enfermedades Metabólicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Islas-Andrade+S%22">Islas-Andrade S</searchLink>; Unidad de Investigación Médica en Enfermedades Metabólicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Soberon+X%22">Soberon X</searchLink>; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Curran+JE%22">Curran JE</searchLink>; South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX.<br /><searchLink fieldCode="AU" term="%22Jenkinson+CP%22">Jenkinson CP</searchLink>; South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX.<br /><searchLink fieldCode="AU" term="%22DeFronzo+RA%22">DeFronzo RA</searchLink>; Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX.<br /><searchLink fieldCode="AU" term="%22Lehman+DM%22">Lehman DM</searchLink>; Departments of Medicine and Cellular & Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX.<br /><searchLink fieldCode="AU" term="%22Hanis+CL%22">Hanis CL</searchLink>; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Bell+GI%22">Bell GI</searchLink>; Department of Medicine, The University of Chicago, Chicago, IL.; Department of Human Genetics, The University of Chicago, Chicago, IL.<br /><searchLink fieldCode="AU" term="%22Boehnke+M%22">Boehnke M</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Blangero+J%22">Blangero J</searchLink>; South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX.<br /><searchLink fieldCode="AU" term="%22Duggirala+R%22">Duggirala R</searchLink>; South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX.<br /><searchLink fieldCode="AU" term="%22Saxena+R%22">Saxena R</searchLink>; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22MacArthur+D%22">MacArthur D</searchLink>; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Ferrer+J%22">Ferrer J</searchLink>; Department of Medicine, Imperial College London, London, U.K.; Genomic Programming of Beta Cells and Diabetes, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.; CIBERDEM, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22McCarroll+SA%22">McCarroll SA</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA.; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Torrents+D%22">Torrents D</searchLink>; Barcelona Supercomputing Center, Joint BSC-CRG-IRB Research Programme in Computational Biology, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Knowler+WC%22">Knowler WC</searchLink>; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ.<br /><searchLink fieldCode="AU" term="%22Baier+LJ%22">Baier LJ</searchLink>; Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ.<br /><searchLink fieldCode="AU" term="%22Burtt+N%22">Burtt N</searchLink>; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22González-Villalpando+C%22">González-Villalpando C</searchLink>; Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Pública, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Haiman+CA%22">Haiman CA</searchLink>; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI.<br /><searchLink fieldCode="AU" term="%22Aguilar-Salinas+CA%22">Aguilar-Salinas CA</searchLink>; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Tusié-Luna+T%22">Tusié-Luna T</searchLink>; Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Flannick+J%22">Flannick J</searchLink>; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Molecular Biology, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Jacobs+SBR%22">Jacobs SBR</searchLink>; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Orozco+L%22">Orozco L</searchLink>; Instituto Nacional de Medicina Genómica, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Altshuler+D%22">Altshuler D</searchLink>; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Genetics, Harvard Medical School, Boston, MA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Molecular Biology, Harvard Medical School, Boston, MA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Florez+JC%22">Florez JC</searchLink>; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA jcflorez@mgh.harvard.edu.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.
– Name: AuthorCorporate
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  Data: <searchLink fieldCode="CA" term="%22Diabetes+Prevention+Program+Research+Group%22">Diabetes Prevention Program Research Group</searchLink><br /><searchLink fieldCode="CA" term="%22Broad+Genomics+Platform%22">Broad Genomics Platform</searchLink><br /><searchLink fieldCode="CA" term="%22T2D-GENES+Consortium%22">T2D-GENES Consortium</searchLink><br /><searchLink fieldCode="CA" term="%22SIGMA+T2D+Genetics+Consortium%22">SIGMA T2D Genetics Consortium</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220372763%22">Diabetes</searchLink> [Diabetes] 2017 Nov; Vol. 66 (11), pp. 2903-2914. <i>Date of Electronic Publication: </i>2017 Aug 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Diabetes+Association%22">American Diabetes Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372763 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1939-327X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200121797%22">00121797 </searchLink><i>NLM ISO Abbreviation: </i>Diabetes <i>Subsets: </i>MEDLINE
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      – TitleFull: A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes.
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