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A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.

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Title: A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.
Authors: Rebecca VW; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Nicastri MC; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania., McLaughlin N; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania., Fennelly C; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., McAfee Q; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Ronghe A; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania., Nofal M; Department of Chemistry and Integrative Genomics, Princeton University, Princeton, New Jersey., Lim CY; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California., Witze E; Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania., Chude CI; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Zhang G; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania., Alicea GM; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania., Piao S; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Murugan S; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Ojha R; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Levi SM; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania., Wei Z; Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey., Barber-Rotenberg JS; Department of Biochemistry and Biophysics, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania., Murphy ME; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania., Mills GB; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Lu Y; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Rabinowitz J; Department of Chemistry and Integrative Genomics, Princeton University, Princeton, New Jersey., Marmorstein R; Department of Biochemistry and Biophysics, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania., Liu Q; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania., Liu S; Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania., Xu X; Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania., Herlyn M; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania., Zoncu R; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California., Brady DC; Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania., Speicher DW; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania., Winkler JD; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania. ravi.amaravadi@uphs.upenn.edu winkler@sas.upenn.edu.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania., Amaravadi RK; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. ravi.amaravadi@uphs.upenn.edu winkler@sas.upenn.edu.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.
Source: Cancer discovery [Cancer Discov] 2017 Nov; Vol. 7 (11), pp. 1266-1283. Date of Electronic Publication: 2017 Sep 12.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Rebecca+VW%22">Rebecca VW</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Nicastri+MC%22">Nicastri MC</searchLink>; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22McLaughlin+N%22">McLaughlin N</searchLink>; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Fennelly+C%22">Fennelly C</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22McAfee+Q%22">McAfee Q</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Ronghe+A%22">Ronghe A</searchLink>; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Nofal+M%22">Nofal M</searchLink>; Department of Chemistry and Integrative Genomics, Princeton University, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Lim+CY%22">Lim CY</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California.<br /><searchLink fieldCode="AU" term="%22Witze+E%22">Witze E</searchLink>; Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Chude+CI%22">Chude CI</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Zhang+G%22">Zhang G</searchLink>; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Alicea+GM%22">Alicea GM</searchLink>; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Piao+S%22">Piao S</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Murugan+S%22">Murugan S</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Ojha+R%22">Ojha R</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Levi+SM%22">Levi SM</searchLink>; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Wei+Z%22">Wei Z</searchLink>; Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey.<br /><searchLink fieldCode="AU" term="%22Barber-Rotenberg+JS%22">Barber-Rotenberg JS</searchLink>; Department of Biochemistry and Biophysics, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Murphy+ME%22">Murphy ME</searchLink>; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Mills+GB%22">Mills GB</searchLink>; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Rabinowitz+J%22">Rabinowitz J</searchLink>; Department of Chemistry and Integrative Genomics, Princeton University, Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Marmorstein+R%22">Marmorstein R</searchLink>; Department of Biochemistry and Biophysics, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Herlyn+M%22">Herlyn M</searchLink>; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Zoncu+R%22">Zoncu R</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California.<br /><searchLink fieldCode="AU" term="%22Brady+DC%22">Brady DC</searchLink>; Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Speicher+DW%22">Speicher DW</searchLink>; Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Wistar Institute, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Winkler+JD%22">Winkler JD</searchLink>; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania. ravi.amaravadi@uphs.upenn.edu winkler@sas.upenn.edu.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Amaravadi+RK%22">Amaravadi RK</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. ravi.amaravadi@uphs.upenn.edu winkler@sas.upenn.edu.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.
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  Data: <searchLink fieldCode="JN" term="%22101561693%22">Cancer discovery</searchLink> [Cancer Discov] 2017 Nov; Vol. 7 (11), pp. 1266-1283. <i>Date of Electronic Publication: </i>2017 Sep 12.
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