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Investigation of Deteriorated Dissolution of Amorphous Itraconazole: Description of Incompatibility with Magnesium Stearate and Possible Solutions.

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Title: Investigation of Deteriorated Dissolution of Amorphous Itraconazole: Description of Incompatibility with Magnesium Stearate and Possible Solutions.
Authors: Démuth B; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary., Galata DL; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary., Szabó E; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary., Nagy B; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary., Farkas A; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary., Balogh A; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary., Hirsch E; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary., Pataki H; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary., Rapi Z; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary., Bezúr L; Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics (BME) , Szent Gellért tér 4, H-1111, Budapest, Hungary., Vigh T; Drug Product Development, Janssen R&D , Turnhoutseweg 30, B-2340 Beerse, Belgium., Verreck G; Drug Product Development, Janssen R&D , Turnhoutseweg 30, B-2340 Beerse, Belgium., Szalay Z; Drug Polymorphism Research, Gedeon Richter Plc. , Gyömrői út 30-32, H-1103 Budapest, Hungary., Demeter Á; Drug Polymorphism Research, Gedeon Richter Plc. , Gyömrői út 30-32, H-1103 Budapest, Hungary., Marosi G; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary., Nagy ZK; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Source: Molecular pharmaceutics [Mol Pharm] 2017 Nov 06; Vol. 14 (11), pp. 3927-3934. Date of Electronic Publication: 2017 Oct 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Investigation of Deteriorated Dissolution of Amorphous Itraconazole: Description of Incompatibility with Magnesium Stearate and Possible Solutions.
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  Data: <searchLink fieldCode="AU" term="%22Démuth+B%22">Démuth B</searchLink>; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Galata+DL%22">Galata DL</searchLink>; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Szabó+E%22">Szabó E</searchLink>; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Nagy+B%22">Nagy B</searchLink>; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Farkas+A%22">Farkas A</searchLink>; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Balogh+A%22">Balogh A</searchLink>; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Hirsch+E%22">Hirsch E</searchLink>; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Pataki+H%22">Pataki H</searchLink>; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Rapi+Z%22">Rapi Z</searchLink>; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Bezúr+L%22">Bezúr L</searchLink>; Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics (BME) , Szent Gellért tér 4, H-1111, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Vigh+T%22">Vigh T</searchLink>; Drug Product Development, Janssen R&D , Turnhoutseweg 30, B-2340 Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Verreck+G%22">Verreck G</searchLink>; Drug Product Development, Janssen R&D , Turnhoutseweg 30, B-2340 Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Szalay+Z%22">Szalay Z</searchLink>; Drug Polymorphism Research, Gedeon Richter Plc. , Gyömrői út 30-32, H-1103 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Demeter+Á%22">Demeter Á</searchLink>; Drug Polymorphism Research, Gedeon Richter Plc. , Gyömrői út 30-32, H-1103 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Marosi+G%22">Marosi G</searchLink>; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Nagy+ZK%22">Nagy ZK</searchLink>; Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME) , Műegyetem rkp. 3, H-1111 Budapest, Hungary.
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  Data: <searchLink fieldCode="JN" term="%22101197791%22">Molecular pharmaceutics</searchLink> [Mol Pharm] 2017 Nov 06; Vol. 14 (11), pp. 3927-3934. <i>Date of Electronic Publication: </i>2017 Oct 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101197791 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1543-8392 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215438384%22">15438384 </searchLink><i>NLM ISO Abbreviation: </i>Mol Pharm <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.molpharmaceut.7b00629
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