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Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewing's sarcoma.

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Title: Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewing's sarcoma.
Authors: Zöllner SK; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.; Department of Pediatric Hematology and Oncology, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149 Münster, Germany., Selvanathan SP; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA., Graham GT; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA., Commins RMT; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA., Hong SH; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA., Moseley E; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA., Parks S; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA., Haladyna JN; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA., Erkizan HV; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA., Dirksen U; Department of Pediatric Hematology and Oncology, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149 Münster, Germany., Hogarty MD; Division of Oncology, Children's Hospital of Philadelphia, Colket Translational Research Building, Room 3020, 3501 Civic Center Boulevard, Philadelphia, PA 19014, USA., Üren A; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA., Toretsky JA; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA. jat42@georgetown.edu.
Source: Science signaling [Sci Signal] 2017 Oct 03; Vol. 10 (499). Date of Electronic Publication: 2017 Oct 03.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
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  Data: Inhibition of the oncogenic fusion protein EWS-FLI1 causes G<subscript>2</subscript>-M cell cycle arrest and enhanced vincristine sensitivity in Ewing's sarcoma.
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  Data: <searchLink fieldCode="AU" term="%22Zöllner+SK%22">Zöllner SK</searchLink>; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.; Department of Pediatric Hematology and Oncology, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Selvanathan+SP%22">Selvanathan SP</searchLink>; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.<br /><searchLink fieldCode="AU" term="%22Graham+GT%22">Graham GT</searchLink>; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.<br /><searchLink fieldCode="AU" term="%22Commins+RMT%22">Commins RMT</searchLink>; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.<br /><searchLink fieldCode="AU" term="%22Hong+SH%22">Hong SH</searchLink>; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.<br /><searchLink fieldCode="AU" term="%22Moseley+E%22">Moseley E</searchLink>; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.<br /><searchLink fieldCode="AU" term="%22Parks+S%22">Parks S</searchLink>; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.<br /><searchLink fieldCode="AU" term="%22Haladyna+JN%22">Haladyna JN</searchLink>; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.<br /><searchLink fieldCode="AU" term="%22Erkizan+HV%22">Erkizan HV</searchLink>; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.<br /><searchLink fieldCode="AU" term="%22Dirksen+U%22">Dirksen U</searchLink>; Department of Pediatric Hematology and Oncology, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Hogarty+MD%22">Hogarty MD</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Colket Translational Research Building, Room 3020, 3501 Civic Center Boulevard, Philadelphia, PA 19014, USA.<br /><searchLink fieldCode="AU" term="%22Üren+A%22">Üren A</searchLink>; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.<br /><searchLink fieldCode="AU" term="%22Toretsky+JA%22">Toretsky JA</searchLink>; Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA. jat42@georgetown.edu.
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  Data: <searchLink fieldCode="JN" term="%22101465400%22">Science signaling</searchLink> [Sci Signal] 2017 Oct 03; Vol. 10 (499). <i>Date of Electronic Publication: </i>2017 Oct 03.
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