Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses.

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Title: Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses.
Authors: Vogel AB; BioNTech RNA Pharmaceuticals GmbH, An der Goldgrube 12, 55131 Mainz, Germany. Electronic address: annette.vogel@biontech.de., Lambert L; Mucosal Infection and Immunity Group, Section of Virology, Department of Medicine, St. Mary's Campus, Imperial College London W2 1PG, UK., Kinnear E; Mucosal Infection and Immunity Group, Section of Virology, Department of Medicine, St. Mary's Campus, Imperial College London W2 1PG, UK., Busse D; Mucosal Infection and Immunity Group, Section of Virology, Department of Medicine, St. Mary's Campus, Imperial College London W2 1PG, UK., Erbar S; BioNTech RNA Pharmaceuticals GmbH, An der Goldgrube 12, 55131 Mainz, Germany., Reuter KC; BioNTech AG, An der Goldgrube 12, 55131 Mainz, Germany., Wicke L; BioNTech RNA Pharmaceuticals GmbH, An der Goldgrube 12, 55131 Mainz, Germany., Perkovic M; TRON GmbH, Freiligrathstraße 12, 55131 Mainz, Germany., Beissert T; TRON GmbH, Freiligrathstraße 12, 55131 Mainz, Germany., Haas H; BioNTech RNA Pharmaceuticals GmbH, An der Goldgrube 12, 55131 Mainz, Germany., Reece ST; BioNTech RNA Pharmaceuticals GmbH, An der Goldgrube 12, 55131 Mainz, Germany., Sahin U; BioNTech AG, An der Goldgrube 12, 55131 Mainz, Germany., Tregoning JS; Mucosal Infection and Immunity Group, Section of Virology, Department of Medicine, St. Mary's Campus, Imperial College London W2 1PG, UK. Electronic address: john.tregoning@imperial.ac.uk.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2018 Feb 07; Vol. 26 (2), pp. 446-455. Date of Electronic Publication: 2017 Dec 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1525-0024
DOI:10.1016/j.ymthe.2017.11.017