Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species.
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| Title: | Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species. |
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| Authors: | Chen XQ; Discovery Pharmaceutics, Bristol-Myers Squibb, Princeton, New Jersey 08540. Electronic address: xue-qing.chen@bms.com., Ziemba T; Discovery Pharmaceutics, Bristol-Myers Squibb, Princeton, New Jersey 08540., Huang C; Metabolism and Pharmacokinetics, Bristol-Myers Squibb, Princeton, New Jersey 08540., Chang M; Clinical Pharmacology and Pharmacometrics, Bristol-Myers Squibb, Pennington, New Jersey 08534., Xu C; Bioanalytical Sciences, Bristol-Myers Squibb, Princeton, New Jersey 08540., Qiao JX; Discovery Chemistry, Bristol-Myers Squibb, Pennington, New Jersey 08540., Wang TC; Discovery Chemistry, Bristol-Myers Squibb, Pennington, New Jersey 08540., Finlay HJ; Discovery Chemistry, Bristol-Myers Squibb, Pennington, New Jersey 08540., Salvati ME; Discovery Chemistry, Bristol-Myers Squibb, Pennington, New Jersey 08540., Adam LP; Discovery Biology, Bristol-Myers Squibb, Pennington, New Jersey 08540., Gudmundsson O; Discovery Pharmaceutics, Bristol-Myers Squibb, Princeton, New Jersey 08540., Hageman MJ; Discovery Pharmaceutics, Bristol-Myers Squibb, Princeton, New Jersey 08540. |
| Source: | Journal of pharmaceutical sciences [J Pharm Sci] 2018 May; Vol. 107 (5), pp. 1352-1360. Date of Electronic Publication: 2018 Jan 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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