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Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis.

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Title: Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis.
Authors: Ates LS; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, The Netherlands. Louis.Ates@gmail.com.; Unit for Integrated Mycobacterial Pathogenomics, Institut Pasteur, Paris, France. Louis.Ates@gmail.com., Dippenaar A; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa., Ummels R; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, The Netherlands., Piersma SR; Department of Medical Oncology, OncoProteomics Laboratory, VU University Medical Center, Amsterdam, Netherlands., van der Woude AD; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, The Netherlands., van der Kuij K; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, The Netherlands., Le Chevalier F; Unit for Integrated Mycobacterial Pathogenomics, Institut Pasteur, Paris, France., Mata-Espinosa D; Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', México City, Mexico., Barrios-Payán J; Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', México City, Mexico., Marquina-Castillo B; Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', México City, Mexico., Guapillo C; Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', México City, Mexico., Jiménez CR; Department of Medical Oncology, OncoProteomics Laboratory, VU University Medical Center, Amsterdam, Netherlands., Pain A; Pathogen Genomics Laboratory, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Houben ENG; Section Molecular Microbiology, Amsterdam Institute of Molecules, Medicine & Systems, Vrije Universiteit, Amsterdam, The Netherlands., Warren RM; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa., Brosch R; Unit for Integrated Mycobacterial Pathogenomics, Institut Pasteur, Paris, France., Hernández-Pando R; Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', México City, Mexico., Bitter W; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, The Netherlands. W.Bitter@vumc.nl.; Section Molecular Microbiology, Amsterdam Institute of Molecules, Medicine & Systems, Vrije Universiteit, Amsterdam, The Netherlands. W.Bitter@vumc.nl.
Source: Nature microbiology [Nat Microbiol] 2018 Feb; Vol. 3 (2), pp. 181-188. Date of Electronic Publication: 2018 Jan 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mutations in ppe38 block PE_PGRS secretion and increase virulence of Mycobacterium tuberculosis.
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  Data: <searchLink fieldCode="AU" term="%22Ates+LS%22">Ates LS</searchLink>; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, The Netherlands. Louis.Ates@gmail.com.; Unit for Integrated Mycobacterial Pathogenomics, Institut Pasteur, Paris, France. Louis.Ates@gmail.com.<br /><searchLink fieldCode="AU" term="%22Dippenaar+A%22">Dippenaar A</searchLink>; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.<br /><searchLink fieldCode="AU" term="%22Ummels+R%22">Ummels R</searchLink>; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Piersma+SR%22">Piersma SR</searchLink>; Department of Medical Oncology, OncoProteomics Laboratory, VU University Medical Center, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Woude+AD%22">van der Woude AD</searchLink>; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Kuij+K%22">van der Kuij K</searchLink>; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Le+Chevalier+F%22">Le Chevalier F</searchLink>; Unit for Integrated Mycobacterial Pathogenomics, Institut Pasteur, Paris, France.<br /><searchLink fieldCode="AU" term="%22Mata-Espinosa+D%22">Mata-Espinosa D</searchLink>; Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', México City, Mexico.<br /><searchLink fieldCode="AU" term="%22Barrios-Payán+J%22">Barrios-Payán J</searchLink>; Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', México City, Mexico.<br /><searchLink fieldCode="AU" term="%22Marquina-Castillo+B%22">Marquina-Castillo B</searchLink>; Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', México City, Mexico.<br /><searchLink fieldCode="AU" term="%22Guapillo+C%22">Guapillo C</searchLink>; Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', México City, Mexico.<br /><searchLink fieldCode="AU" term="%22Jiménez+CR%22">Jiménez CR</searchLink>; Department of Medical Oncology, OncoProteomics Laboratory, VU University Medical Center, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Pain+A%22">Pain A</searchLink>; Pathogen Genomics Laboratory, BESE Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Houben+ENG%22">Houben ENG</searchLink>; Section Molecular Microbiology, Amsterdam Institute of Molecules, Medicine & Systems, Vrije Universiteit, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Warren+RM%22">Warren RM</searchLink>; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.<br /><searchLink fieldCode="AU" term="%22Brosch+R%22">Brosch R</searchLink>; Unit for Integrated Mycobacterial Pathogenomics, Institut Pasteur, Paris, France.<br /><searchLink fieldCode="AU" term="%22Hernández-Pando+R%22">Hernández-Pando R</searchLink>; Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition 'Salvador Zubirán', México City, Mexico.<br /><searchLink fieldCode="AU" term="%22Bitter+W%22">Bitter W</searchLink>; Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, The Netherlands. W.Bitter@vumc.nl.; Section Molecular Microbiology, Amsterdam Institute of Molecules, Medicine & Systems, Vrije Universiteit, Amsterdam, The Netherlands. W.Bitter@vumc.nl.
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  Data: <searchLink fieldCode="JN" term="%22101674869%22">Nature microbiology</searchLink> [Nat Microbiol] 2018 Feb; Vol. 3 (2), pp. 181-188. <i>Date of Electronic Publication: </i>2018 Jan 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101674869 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2058-5276 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220585276%22">20585276 </searchLink><i>NLM ISO Abbreviation: </i>Nat Microbiol <i>Subsets: </i>MEDLINE
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