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Repurposing Tin Mesoporphyrin as an Immune Checkpoint Inhibitor Shows Therapeutic Efficacy in Preclinical Models of Cancer.

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Title: Repurposing Tin Mesoporphyrin as an Immune Checkpoint Inhibitor Shows Therapeutic Efficacy in Preclinical Models of Cancer.
Authors: Muliaditan T; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom., Opzoomer JW; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom., Caron J; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom., Okesola M; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom., Kosti P; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom., Lall S; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom., Van Hemelrijck M; Translational Oncology and Urology Research, School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom., Dazzi F; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom., Tutt A; Breast Cancer Now Unit, School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom., Grigoriadis A; Breast Cancer Now Unit, School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom., Gillett CE; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom., Madden SF; Population Health Sciences Division, Royal College of Surgeons in Ireland, Ireland., Burchell JM; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom., Kordasti S; Department of Hematological Medicine, King's College London, School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, Denmark Hill, London, United Kingdom., Diebold SS; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom., Spicer JF; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom., Arnold JN; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom. james.n.arnold@kcl.ac.uk.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2018 Apr 01; Vol. 24 (7), pp. 1617-1628. Date of Electronic Publication: 2018 Jan 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Muliaditan+T%22">Muliaditan T</searchLink>; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Opzoomer+JW%22">Opzoomer JW</searchLink>; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Caron+J%22">Caron J</searchLink>; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Okesola+M%22">Okesola M</searchLink>; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kosti+P%22">Kosti P</searchLink>; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lall+S%22">Lall S</searchLink>; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Van+Hemelrijck+M%22">Van Hemelrijck M</searchLink>; Translational Oncology and Urology Research, School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dazzi+F%22">Dazzi F</searchLink>; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tutt+A%22">Tutt A</searchLink>; Breast Cancer Now Unit, School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Grigoriadis+A%22">Grigoriadis A</searchLink>; Breast Cancer Now Unit, School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gillett+CE%22">Gillett CE</searchLink>; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Madden+SF%22">Madden SF</searchLink>; Population Health Sciences Division, Royal College of Surgeons in Ireland, Ireland.<br /><searchLink fieldCode="AU" term="%22Burchell+JM%22">Burchell JM</searchLink>; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kordasti+S%22">Kordasti S</searchLink>; Department of Hematological Medicine, King's College London, School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, Denmark Hill, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Diebold+SS%22">Diebold SS</searchLink>; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Spicer+JF%22">Spicer JF</searchLink>; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Arnold+JN%22">Arnold JN</searchLink>; School of Cancer and Pharmaceutical Sciences, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London, United Kingdom. james.n.arnold@kcl.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%229502500%22">Clinical cancer research : an official journal of the American Association for Cancer Research</searchLink> [Clin Cancer Res] 2018 Apr 01; Vol. 24 (7), pp. 1617-1628. <i>Date of Electronic Publication: </i>2018 Jan 16.
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