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Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms.

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Title: Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms.
Authors: Pridgeon CS; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, UK., Schlott C; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, UK., Wong MW; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, UK., Heringa MB; National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., Heckel T; Dr. Johannes Heidenhain GmbH, Dr.-Johannes-Heidenhain-Straße 5, 83301, Traunreut, Germany., Leedale J; Department of Mathematical Sciences, University of Liverpool, Liverpool, L69 7ZL, UK., Launay L; Technologie Servier, Orléans, France., Gryshkova V; Investigative Toxicology, Department of Non-Clinical Development, UCB Biopharma SPRL, 1420, Braine L'Alleud, Belgium., Przyborski S; Department of Biosciences, Durham University, Durham, DH1 3LE, UK., Bearon RN; Department of Mathematical Sciences, University of Liverpool, Liverpool, L69 7ZL, UK., Wilkinson EL; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, UK., Ansari T; Northwick Park Institute for Medical Research, Northwick Park and St Mark's Hospital, Middlesex, HA1 3UJ, UK., Greenman J; School of Life Sciences, University of Hull, Hull, HU6 7RX, UK., Hendriks DFG; Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Gibbs S; Department of Dermatology, VU University Medical Center, Amsterdam, The Netherlands.; Department of Oral Cell Biology, Academic Center for Dentistry Amsterdam, University of Amsterdam and VU University, Amsterdam, The Netherlands., Sidaway J; Phenotox Ltd, Cheshire, SK10 5QT, UK., Sison-Young RL; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, UK., Walker P; Cyprotex Discovery Ltd, Cheshire, SK10 4TG, UK., Cross MJ; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, UK., Park BK; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, UK., Goldring CEP; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, UK. chrissy@liv.ac.uk.
Source: Archives of toxicology [Arch Toxicol] 2018 Feb; Vol. 92 (2), pp. 557-569. Date of Electronic Publication: 2018 Jan 23.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms.
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  Data: <searchLink fieldCode="AU" term="%22Pridgeon+CS%22">Pridgeon CS</searchLink>; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, UK.<br /><searchLink fieldCode="AU" term="%22Schlott+C%22">Schlott C</searchLink>; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, UK.<br /><searchLink fieldCode="AU" term="%22Wong+MW%22">Wong MW</searchLink>; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, UK.<br /><searchLink fieldCode="AU" term="%22Heringa+MB%22">Heringa MB</searchLink>; National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Heckel+T%22">Heckel T</searchLink>; Dr. Johannes Heidenhain GmbH, Dr.-Johannes-Heidenhain-Straße 5, 83301, Traunreut, Germany.<br /><searchLink fieldCode="AU" term="%22Leedale+J%22">Leedale J</searchLink>; Department of Mathematical Sciences, University of Liverpool, Liverpool, L69 7ZL, UK.<br /><searchLink fieldCode="AU" term="%22Launay+L%22">Launay L</searchLink>; Technologie Servier, Orléans, France.<br /><searchLink fieldCode="AU" term="%22Gryshkova+V%22">Gryshkova V</searchLink>; Investigative Toxicology, Department of Non-Clinical Development, UCB Biopharma SPRL, 1420, Braine L'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Przyborski+S%22">Przyborski S</searchLink>; Department of Biosciences, Durham University, Durham, DH1 3LE, UK.<br /><searchLink fieldCode="AU" term="%22Bearon+RN%22">Bearon RN</searchLink>; Department of Mathematical Sciences, University of Liverpool, Liverpool, L69 7ZL, UK.<br /><searchLink fieldCode="AU" term="%22Wilkinson+EL%22">Wilkinson EL</searchLink>; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, UK.<br /><searchLink fieldCode="AU" term="%22Ansari+T%22">Ansari T</searchLink>; Northwick Park Institute for Medical Research, Northwick Park and St Mark's Hospital, Middlesex, HA1 3UJ, UK.<br /><searchLink fieldCode="AU" term="%22Greenman+J%22">Greenman J</searchLink>; School of Life Sciences, University of Hull, Hull, HU6 7RX, UK.<br /><searchLink fieldCode="AU" term="%22Hendriks+DFG%22">Hendriks DFG</searchLink>; Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Gibbs+S%22">Gibbs S</searchLink>; Department of Dermatology, VU University Medical Center, Amsterdam, The Netherlands.; Department of Oral Cell Biology, Academic Center for Dentistry Amsterdam, University of Amsterdam and VU University, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sidaway+J%22">Sidaway J</searchLink>; Phenotox Ltd, Cheshire, SK10 5QT, UK.<br /><searchLink fieldCode="AU" term="%22Sison-Young+RL%22">Sison-Young RL</searchLink>; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, UK.<br /><searchLink fieldCode="AU" term="%22Walker+P%22">Walker P</searchLink>; Cyprotex Discovery Ltd, Cheshire, SK10 4TG, UK.<br /><searchLink fieldCode="AU" term="%22Cross+MJ%22">Cross MJ</searchLink>; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, UK.<br /><searchLink fieldCode="AU" term="%22Park+BK%22">Park BK</searchLink>; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, UK.<br /><searchLink fieldCode="AU" term="%22Goldring+CEP%22">Goldring CEP</searchLink>; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GE, UK. chrissy@liv.ac.uk.
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