Probing Ligand Structure-Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation.
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| Title: | Probing Ligand Structure-Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation. |
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| Authors: | Narayanan B; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Hunterian 709, Baltimore, MD, USA., Lade JM; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Biophysics 307, Baltimore, MD, USA., Heck CJS; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Biophysics 307, Baltimore, MD, USA., Dietz KD; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Hunterian 709, Baltimore, MD, USA., Wade H; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Hunterian 709, Baltimore, MD, USA., Bumpus NN; Department of Medicine, Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Biophysics 307, Baltimore, MD, USA. |
| Source: | ChemMedChem [ChemMedChem] 2018 Apr 06; Vol. 13 (7), pp. 736-747. Date of Electronic Publication: 2018 Mar 02. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1860-7187 |
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| DOI: | 10.1002/cmdc.201700730 |
