Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase.

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Title: Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase.
Authors: Ruf S; Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany. Electronic address: Sven.Ruf@sanofi.com., Hallur MS; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Anchan NK; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Swamy IN; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Murugesan KR; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Sarkar S; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Narasimhulu LK; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Putta VPRK; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Shaik S; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India., Chandrasekar DV; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Mane VS; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India., Kadnur SV; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India., Suresh J; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India., Bhamidipati RK; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Singh M; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Burri RR; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Kristam R; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Schreuder H; Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany., Czech J; Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany., Rudolph C; Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany., Marker A; R&D Drug Metabolism & Pharmacokinetics, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany., Langer T; Biologics Research, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany., Mullangi R; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Yura T; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Gosu R; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Kannt A; R&D Diabetes, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany; Institute of Experimental Pharmacology, Medical Faculty Mannheim, University of Heidelberg, D-68167 Mannheim, Germany., Dhakshinamoorthy S; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India., Rajagopal S; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India. Electronic address: sridharan_rajagopal@jubilantbiosys.com.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Mar 01; Vol. 28 (5), pp. 922-925. Date of Electronic Publication: 2018 Jan 31.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1464-3405
DOI:10.1016/j.bmcl.2018.01.058