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Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase.

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Title: Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase.
Authors: Ruf S; Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany. Electronic address: Sven.Ruf@sanofi.com., Hallur MS; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Anchan NK; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Swamy IN; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Murugesan KR; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Sarkar S; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Narasimhulu LK; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Putta VPRK; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Shaik S; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India., Chandrasekar DV; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Mane VS; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India., Kadnur SV; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India., Suresh J; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India., Bhamidipati RK; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Singh M; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Burri RR; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Kristam R; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Schreuder H; Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany., Czech J; Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany., Rudolph C; Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany., Marker A; R&D Drug Metabolism & Pharmacokinetics, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany., Langer T; Biologics Research, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany., Mullangi R; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Yura T; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Gosu R; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Kannt A; R&D Diabetes, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany; Institute of Experimental Pharmacology, Medical Faculty Mannheim, University of Heidelberg, D-68167 Mannheim, Germany., Dhakshinamoorthy S; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India., Rajagopal S; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India. Electronic address: sridharan_rajagopal@jubilantbiosys.com.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Mar 01; Vol. 28 (5), pp. 922-925. Date of Electronic Publication: 2018 Jan 31.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
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  Data: Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase.
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  Data: <searchLink fieldCode="AU" term="%22Ruf+S%22">Ruf S</searchLink>; Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany. Electronic address: Sven.Ruf@sanofi.com.<br /><searchLink fieldCode="AU" term="%22Hallur+MS%22">Hallur MS</searchLink>; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Anchan+NK%22">Anchan NK</searchLink>; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Swamy+IN%22">Swamy IN</searchLink>; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Murugesan+KR%22">Murugesan KR</searchLink>; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Sarkar+S%22">Sarkar S</searchLink>; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Narasimhulu+LK%22">Narasimhulu LK</searchLink>; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Putta+VPRK%22">Putta VPRK</searchLink>; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Shaik+S%22">Shaik S</searchLink>; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Chandrasekar+DV%22">Chandrasekar DV</searchLink>; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Mane+VS%22">Mane VS</searchLink>; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Kadnur+SV%22">Kadnur SV</searchLink>; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Suresh+J%22">Suresh J</searchLink>; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Bhamidipati+RK%22">Bhamidipati RK</searchLink>; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Singh+M%22">Singh M</searchLink>; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Burri+RR%22">Burri RR</searchLink>; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Kristam+R%22">Kristam R</searchLink>; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Schreuder+H%22">Schreuder H</searchLink>; Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Czech+J%22">Czech J</searchLink>; Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Rudolph+C%22">Rudolph C</searchLink>; Integrated Drug Discovery, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Marker+A%22">Marker A</searchLink>; R&D Drug Metabolism & Pharmacokinetics, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Langer+T%22">Langer T</searchLink>; Biologics Research, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Mullangi+R%22">Mullangi R</searchLink>; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Yura+T%22">Yura T</searchLink>; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Gosu+R%22">Gosu R</searchLink>; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Kannt+A%22">Kannt A</searchLink>; R&D Diabetes, Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main, Germany; Institute of Experimental Pharmacology, Medical Faculty Mannheim, University of Heidelberg, D-68167 Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Dhakshinamoorthy+S%22">Dhakshinamoorthy S</searchLink>; Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore 560022, India; Department of Drug Metabolism and Pharmacokinetics, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Rajagopal+S%22">Rajagopal S</searchLink>; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India. Electronic address: sridharan_rajagopal@jubilantbiosys.com.
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2018 Mar 01; Vol. 28 (5), pp. 922-925. <i>Date of Electronic Publication: </i>2018 Jan 31.
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