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Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement.

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Title: Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement.
Authors: Ugurlar D; Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands., Howes SC; Section of Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, Netherlands., de Kreuk BJ; Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands., Koning RI; Section of Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, Netherlands.; NeCEN, Gorlaeus Laboratories, Leiden University, 2333 CC Leiden, Netherlands., de Jong RN; Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands., Beurskens FJ; Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands., Schuurman J; Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands., Koster AJ; Section of Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, Netherlands.; NeCEN, Gorlaeus Laboratories, Leiden University, 2333 CC Leiden, Netherlands., Sharp TH; Section of Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, Netherlands. t.sharp@lumc.nl p.w.h.i.parren@lumc.nl p.gros@uu.nl., Parren PWHI; Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands. t.sharp@lumc.nl p.w.h.i.parren@lumc.nl p.gros@uu.nl.; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands., Gros P; Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands. t.sharp@lumc.nl p.w.h.i.parren@lumc.nl p.gros@uu.nl.
Source: Science (New York, N.Y.) [Science] 2018 Feb 16; Vol. 359 (6377), pp. 794-797.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement.
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  Data: <searchLink fieldCode="AU" term="%22Ugurlar+D%22">Ugurlar D</searchLink>; Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Howes+SC%22">Howes SC</searchLink>; Section of Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Kreuk+BJ%22">de Kreuk BJ</searchLink>; Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Koning+RI%22">Koning RI</searchLink>; Section of Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, Netherlands.; NeCEN, Gorlaeus Laboratories, Leiden University, 2333 CC Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Jong+RN%22">de Jong RN</searchLink>; Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Beurskens+FJ%22">Beurskens FJ</searchLink>; Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Schuurman+J%22">Schuurman J</searchLink>; Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Koster+AJ%22">Koster AJ</searchLink>; Section of Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, Netherlands.; NeCEN, Gorlaeus Laboratories, Leiden University, 2333 CC Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Sharp+TH%22">Sharp TH</searchLink>; Section of Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, Netherlands. t.sharp@lumc.nl p.w.h.i.parren@lumc.nl p.gros@uu.nl.<br /><searchLink fieldCode="AU" term="%22Parren+PWHI%22">Parren PWHI</searchLink>; Genmab, Yalelaan 60, 3584 CM Utrecht, Netherlands. t.sharp@lumc.nl p.w.h.i.parren@lumc.nl p.gros@uu.nl.; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Gros+P%22">Gros P</searchLink>; Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands. t.sharp@lumc.nl p.w.h.i.parren@lumc.nl p.gros@uu.nl.
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              Text: 2018 Feb 16
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