2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.
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| Title: | 2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization. |
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| Authors: | Murugesan D; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Ray PC; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Bayliss T; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Prosser GA; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease , National Institutes of Health , 9000 Rockville Pike , Bethesda , Maryland 20892 , United States., Harrison JR; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Green K; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Soares de Melo C; Drug Discovery and Development Centre (H3D), Department of Chemistry , University of Cape Town , Rondebosch , 7701 , South Africa., Feng TS; Drug Discovery and Development Centre (H3D), Department of Chemistry , University of Cape Town , Rondebosch , 7701 , South Africa., Street LJ; Drug Discovery and Development Centre (H3D), Department of Chemistry , University of Cape Town , Rondebosch , 7701 , South Africa., Chibale K; Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch , 7701 , South Africa.; Drug Discovery and Development Centre (H3D), Department of Chemistry , University of Cape Town , Rondebosch , 7701 , South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry , University of Cape Town , Rondebosch , 7701 , South Africa., Warner DF; Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch , 7701 , South Africa.; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, Faculty of Health Sciences , University of Cape Town , Rondebosch , 7701 , South Africa., Mizrahi V; Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch , 7701 , South Africa.; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, Faculty of Health Sciences , University of Cape Town , Rondebosch , 7701 , South Africa., Epemolu O; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Scullion P; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Ellis L; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Riley J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Shishikura Y; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Ferguson L; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Osuna-Cabello M; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Read KD; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Green SR; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Lamprecht DA; Africa Health Research Institute (AHRI) , K-RITH Tower Building Level 3, 719 Umbilo Road , Durban , 4001 , South Africa., Finin PM; Africa Health Research Institute (AHRI) , K-RITH Tower Building Level 3, 719 Umbilo Road , Durban , 4001 , South Africa., Steyn AJC; Africa Health Research Institute (AHRI) , K-RITH Tower Building Level 3, 719 Umbilo Road , Durban , 4001 , South Africa.; Department of Microbiology , University of Alabama at Birmingham , 1720 Second Avenue South , Birmingham , Alabama 35294-2170 , United States., Ioerger TR; Department of Computer Science and Engineering , Texas A&M University , College Station , Texas 77843 , United States., Sacchettini J; Department of Computer Science and Engineering , Texas A&M University , College Station , Texas 77843 , United States., Rhee KY; Division of Infectious Diseases, Weill Department of Medicine , Weill Cornell Medical College , New York , New York 10065 , United States., Arora K; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease , National Institutes of Health , 9000 Rockville Pike , Bethesda , Maryland 20892 , United States., Barry CE 3rd; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease , National Institutes of Health , 9000 Rockville Pike , Bethesda , Maryland 20892 , United States.; Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch , 7701 , South Africa., Wyatt PG; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Boshoff HIM; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease , National Institutes of Health , 9000 Rockville Pike , Bethesda , Maryland 20892 , United States. |
| Source: | ACS infectious diseases [ACS Infect Dis] 2018 Jun 08; Vol. 4 (6), pp. 954-969. Date of Electronic Publication: 2018 Mar 26. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 29522317 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: 2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Murugesan+D%22">Murugesan D</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ray+PC%22">Ray PC</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bayliss+T%22">Bayliss T</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Prosser+GA%22">Prosser GA</searchLink>; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease , National Institutes of Health , 9000 Rockville Pike , Bethesda , Maryland 20892 , United States.<br /><searchLink fieldCode="AU" term="%22Harrison+JR%22">Harrison JR</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Green+K%22">Green K</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Soares+de+Melo+C%22">Soares de Melo C</searchLink>; Drug Discovery and Development Centre (H3D), Department of Chemistry , University of Cape Town , Rondebosch , 7701 , South Africa.<br /><searchLink fieldCode="AU" term="%22Feng+TS%22">Feng TS</searchLink>; Drug Discovery and Development Centre (H3D), Department of Chemistry , University of Cape Town , Rondebosch , 7701 , South Africa.<br /><searchLink fieldCode="AU" term="%22Street+LJ%22">Street LJ</searchLink>; Drug Discovery and Development Centre (H3D), Department of Chemistry , University of Cape Town , Rondebosch , 7701 , South Africa.<br /><searchLink fieldCode="AU" term="%22Chibale+K%22">Chibale K</searchLink>; Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch , 7701 , South Africa.; Drug Discovery and Development Centre (H3D), Department of Chemistry , University of Cape Town , Rondebosch , 7701 , South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry , University of Cape Town , Rondebosch , 7701 , South Africa.<br /><searchLink fieldCode="AU" term="%22Warner+DF%22">Warner DF</searchLink>; Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch , 7701 , South Africa.; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, Faculty of Health Sciences , University of Cape Town , Rondebosch , 7701 , South Africa.<br /><searchLink fieldCode="AU" term="%22Mizrahi+V%22">Mizrahi V</searchLink>; Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch , 7701 , South Africa.; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, Faculty of Health Sciences , University of Cape Town , Rondebosch , 7701 , South Africa.<br /><searchLink fieldCode="AU" term="%22Epemolu+O%22">Epemolu O</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Scullion+P%22">Scullion P</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ellis+L%22">Ellis L</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Riley+J%22">Riley J</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Shishikura+Y%22">Shishikura Y</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ferguson+L%22">Ferguson L</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Osuna-Cabello+M%22">Osuna-Cabello M</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Read+KD%22">Read KD</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Green+SR%22">Green SR</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lamprecht+DA%22">Lamprecht DA</searchLink>; Africa Health Research Institute (AHRI) , K-RITH Tower Building Level 3, 719 Umbilo Road , Durban , 4001 , South Africa.<br /><searchLink fieldCode="AU" term="%22Finin+PM%22">Finin PM</searchLink>; Africa Health Research Institute (AHRI) , K-RITH Tower Building Level 3, 719 Umbilo Road , Durban , 4001 , South Africa.<br /><searchLink fieldCode="AU" term="%22Steyn+AJC%22">Steyn AJC</searchLink>; Africa Health Research Institute (AHRI) , K-RITH Tower Building Level 3, 719 Umbilo Road , Durban , 4001 , South Africa.; Department of Microbiology , University of Alabama at Birmingham , 1720 Second Avenue South , Birmingham , Alabama 35294-2170 , United States.<br /><searchLink fieldCode="AU" term="%22Ioerger+TR%22">Ioerger TR</searchLink>; Department of Computer Science and Engineering , Texas A&M University , College Station , Texas 77843 , United States.<br /><searchLink fieldCode="AU" term="%22Sacchettini+J%22">Sacchettini J</searchLink>; Department of Computer Science and Engineering , Texas A&M University , College Station , Texas 77843 , United States.<br /><searchLink fieldCode="AU" term="%22Rhee+KY%22">Rhee KY</searchLink>; Division of Infectious Diseases, Weill Department of Medicine , Weill Cornell Medical College , New York , New York 10065 , United States.<br /><searchLink fieldCode="AU" term="%22Arora+K%22">Arora K</searchLink>; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease , National Institutes of Health , 9000 Rockville Pike , Bethesda , Maryland 20892 , United States.<br /><searchLink fieldCode="AU" term="%22Barry+CE+3rd%22">Barry CE 3rd</searchLink>; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease , National Institutes of Health , 9000 Rockville Pike , Bethesda , Maryland 20892 , United States.; Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch , 7701 , South Africa.<br /><searchLink fieldCode="AU" term="%22Wyatt+PG%22">Wyatt PG</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom.<br /><searchLink fieldCode="AU" term="%22Boshoff+HIM%22">Boshoff HIM</searchLink>; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease , National Institutes of Health , 9000 Rockville Pike , Bethesda , Maryland 20892 , United States. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101654580%22">ACS infectious diseases</searchLink> [ACS Infect Dis] 2018 Jun 08; Vol. 4 (6), pp. 954-969. <i>Date of Electronic Publication: </i>2018 Mar 26. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22ACS+Publications%22">ACS Publications </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101654580 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2373-8227 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223738227%22">23738227 </searchLink><i>NLM ISO Abbreviation: </i>ACS Infect Dis <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acsinfecdis.7b00275 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 954 Titles: – TitleFull: 2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Murugesan D – PersonEntity: Name: NameFull: Ray PC – PersonEntity: Name: NameFull: Bayliss T – PersonEntity: Name: NameFull: Prosser GA – PersonEntity: Name: NameFull: Harrison JR – PersonEntity: Name: NameFull: Green K – PersonEntity: Name: NameFull: Soares de Melo C – PersonEntity: Name: NameFull: Feng TS – PersonEntity: Name: NameFull: Street LJ – PersonEntity: Name: NameFull: Chibale K – PersonEntity: Name: NameFull: Warner DF – PersonEntity: Name: NameFull: Mizrahi V – PersonEntity: Name: NameFull: Epemolu O – PersonEntity: Name: NameFull: Scullion P – PersonEntity: Name: NameFull: Ellis L – PersonEntity: Name: NameFull: Riley J – PersonEntity: Name: NameFull: Shishikura Y – PersonEntity: Name: NameFull: Ferguson L – PersonEntity: Name: NameFull: Osuna-Cabello M – PersonEntity: Name: NameFull: Read KD – PersonEntity: Name: NameFull: Green SR – PersonEntity: Name: NameFull: Lamprecht DA – PersonEntity: Name: NameFull: Finin PM – PersonEntity: Name: NameFull: Steyn AJC – PersonEntity: Name: NameFull: Ioerger TR – PersonEntity: Name: NameFull: Sacchettini J – PersonEntity: Name: NameFull: Rhee KY – PersonEntity: Name: NameFull: Arora K – PersonEntity: Name: NameFull: Barry CE 3rd – PersonEntity: Name: NameFull: Wyatt PG – PersonEntity: Name: NameFull: Boshoff HIM IsPartOfRelationships: – BibEntity: Dates: – D: 08 M: 06 Text: 2018 Jun 08 Type: published Y: 2018 Identifiers: – Type: issn-electronic Value: 2373-8227 Numbering: – Type: volume Value: 4 – Type: issue Value: 6 Titles: – TitleFull: ACS infectious diseases Type: main |
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