2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.

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Title: 2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.
Authors: Murugesan D; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Ray PC; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Bayliss T; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Prosser GA; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease , National Institutes of Health , 9000 Rockville Pike , Bethesda , Maryland 20892 , United States., Harrison JR; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Green K; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Soares de Melo C; Drug Discovery and Development Centre (H3D), Department of Chemistry , University of Cape Town , Rondebosch , 7701 , South Africa., Feng TS; Drug Discovery and Development Centre (H3D), Department of Chemistry , University of Cape Town , Rondebosch , 7701 , South Africa., Street LJ; Drug Discovery and Development Centre (H3D), Department of Chemistry , University of Cape Town , Rondebosch , 7701 , South Africa., Chibale K; Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch , 7701 , South Africa.; Drug Discovery and Development Centre (H3D), Department of Chemistry , University of Cape Town , Rondebosch , 7701 , South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry , University of Cape Town , Rondebosch , 7701 , South Africa., Warner DF; Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch , 7701 , South Africa.; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, Faculty of Health Sciences , University of Cape Town , Rondebosch , 7701 , South Africa., Mizrahi V; Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch , 7701 , South Africa.; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, Faculty of Health Sciences , University of Cape Town , Rondebosch , 7701 , South Africa., Epemolu O; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Scullion P; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Ellis L; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Riley J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Shishikura Y; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Ferguson L; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Osuna-Cabello M; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Read KD; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Green SR; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Lamprecht DA; Africa Health Research Institute (AHRI) , K-RITH Tower Building Level 3, 719 Umbilo Road , Durban , 4001 , South Africa., Finin PM; Africa Health Research Institute (AHRI) , K-RITH Tower Building Level 3, 719 Umbilo Road , Durban , 4001 , South Africa., Steyn AJC; Africa Health Research Institute (AHRI) , K-RITH Tower Building Level 3, 719 Umbilo Road , Durban , 4001 , South Africa.; Department of Microbiology , University of Alabama at Birmingham , 1720 Second Avenue South , Birmingham , Alabama 35294-2170 , United States., Ioerger TR; Department of Computer Science and Engineering , Texas A&M University , College Station , Texas 77843 , United States., Sacchettini J; Department of Computer Science and Engineering , Texas A&M University , College Station , Texas 77843 , United States., Rhee KY; Division of Infectious Diseases, Weill Department of Medicine , Weill Cornell Medical College , New York , New York 10065 , United States., Arora K; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease , National Institutes of Health , 9000 Rockville Pike , Bethesda , Maryland 20892 , United States., Barry CE 3rd; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease , National Institutes of Health , 9000 Rockville Pike , Bethesda , Maryland 20892 , United States.; Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch , 7701 , South Africa., Wyatt PG; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Sir James Black Centre , Dundee , DD1 5EH , United Kingdom., Boshoff HIM; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease , National Institutes of Health , 9000 Rockville Pike , Bethesda , Maryland 20892 , United States.
Source: ACS infectious diseases [ACS Infect Dis] 2018 Jun 08; Vol. 4 (6), pp. 954-969. Date of Electronic Publication: 2018 Mar 26.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2373-8227
DOI:10.1021/acsinfecdis.7b00275