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Anti-CTLA-4 therapy requires an Fc domain for efficacy.

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Bibliographic Details
Title: Anti-CTLA-4 therapy requires an Fc domain for efficacy.
Authors: Ingram JR; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215., Blomberg OS; Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115., Rashidian M; Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115., Ali L; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215., Garforth S; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Fedorov E; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Fedorov AA; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Bonanno JB; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Le Gall C; Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115., Crowley S; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215., Espinosa C; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215., Biary T; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114., Keliher EJ; Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Radiology, Massachusetts General Hospital, Boston, MA 02114., Weissleder R; Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Radiology, Massachusetts General Hospital, Boston, MA 02114., Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Dougan SK; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215., Ploegh HL; Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115; hidde.ploegh@childrens.harvard.edu mldougan@partners.org., Dougan M; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114; hidde.ploegh@childrens.harvard.edu mldougan@partners.org.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Apr 10; Vol. 115 (15), pp. 3912-3917. Date of Electronic Publication: 2018 Mar 26.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.1801524115