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Anti-CTLA-4 therapy requires an Fc domain for efficacy.

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Title: Anti-CTLA-4 therapy requires an Fc domain for efficacy.
Authors: Ingram JR; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215., Blomberg OS; Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115., Rashidian M; Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115., Ali L; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215., Garforth S; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Fedorov E; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Fedorov AA; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Bonanno JB; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Le Gall C; Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115., Crowley S; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215., Espinosa C; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215., Biary T; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114., Keliher EJ; Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Radiology, Massachusetts General Hospital, Boston, MA 02114., Weissleder R; Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Radiology, Massachusetts General Hospital, Boston, MA 02114., Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Dougan SK; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215., Ploegh HL; Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115; hidde.ploegh@childrens.harvard.edu mldougan@partners.org., Dougan M; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114; hidde.ploegh@childrens.harvard.edu mldougan@partners.org.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Apr 10; Vol. 115 (15), pp. 3912-3917. Date of Electronic Publication: 2018 Mar 26.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Ingram+JR%22">Ingram JR</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215.<br /><searchLink fieldCode="AU" term="%22Blomberg+OS%22">Blomberg OS</searchLink>; Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Rashidian+M%22">Rashidian M</searchLink>; Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Ali+L%22">Ali L</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215.<br /><searchLink fieldCode="AU" term="%22Garforth+S%22">Garforth S</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.<br /><searchLink fieldCode="AU" term="%22Fedorov+E%22">Fedorov E</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.<br /><searchLink fieldCode="AU" term="%22Fedorov+AA%22">Fedorov AA</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.<br /><searchLink fieldCode="AU" term="%22Bonanno+JB%22">Bonanno JB</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.<br /><searchLink fieldCode="AU" term="%22Le+Gall+C%22">Le Gall C</searchLink>; Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Crowley+S%22">Crowley S</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215.<br /><searchLink fieldCode="AU" term="%22Espinosa+C%22">Espinosa C</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215.<br /><searchLink fieldCode="AU" term="%22Biary+T%22">Biary T</searchLink>; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114.<br /><searchLink fieldCode="AU" term="%22Keliher+EJ%22">Keliher EJ</searchLink>; Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Radiology, Massachusetts General Hospital, Boston, MA 02114.<br /><searchLink fieldCode="AU" term="%22Weissleder+R%22">Weissleder R</searchLink>; Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Radiology, Massachusetts General Hospital, Boston, MA 02114.<br /><searchLink fieldCode="AU" term="%22Almo+SC%22">Almo SC</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.<br /><searchLink fieldCode="AU" term="%22Dougan+SK%22">Dougan SK</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215.<br /><searchLink fieldCode="AU" term="%22Ploegh+HL%22">Ploegh HL</searchLink>; Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115; hidde.ploegh@childrens.harvard.edu mldougan@partners.org.<br /><searchLink fieldCode="AU" term="%22Dougan+M%22">Dougan M</searchLink>; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114; hidde.ploegh@childrens.harvard.edu mldougan@partners.org.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2018 Apr 10; Vol. 115 (15), pp. 3912-3917. <i>Date of Electronic Publication: </i>2018 Mar 26.
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