Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5.
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| Title: | Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5. |
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| Authors: | Rossi Sebastiano M; Department of Chemistry - BMC , Uppsala University , Box 576, SE-751 23 Uppsala , Sweden., Doak BC; Department of Medicinal Chemistry, MIPS , Monash University , 381 Royal Parade , Parkville , Victoria 3052 , Australia., Backlund M; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), a Node at the Chemical Biology Consortium Sweden, Science for Life Laboratory, Department of Pharmacy, BMC , Uppsala University , Box 580, SE-751 23 Uppsala , Sweden., Poongavanam V; Department of Chemistry - BMC , Uppsala University , Box 576, SE-751 23 Uppsala , Sweden., Over B; Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit , AstraZeneca R&D Gothenburg , SE-431 83 Mölndal , Sweden., Ermondi G; Department of Molecular Biotechnology and Health Sciences , University of Torino , Quarello 15 , 10135 Torino , Italy., Caron G; Department of Molecular Biotechnology and Health Sciences , University of Torino , Quarello 15 , 10135 Torino , Italy., Matsson P; Department of Pharmacy, BMC , Uppsala University , Box 580, SE-751 23 Uppsala , Sweden., Kihlberg J; Department of Chemistry - BMC , Uppsala University , Box 576, SE-751 23 Uppsala , Sweden. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2018 May 10; Vol. 61 (9), pp. 4189-4202. Date of Electronic Publication: 2018 Apr 16. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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