Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5.

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Bibliographic Details
Title: Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5.
Authors: Rossi Sebastiano M; Department of Chemistry - BMC , Uppsala University , Box 576, SE-751 23 Uppsala , Sweden., Doak BC; Department of Medicinal Chemistry, MIPS , Monash University , 381 Royal Parade , Parkville , Victoria 3052 , Australia., Backlund M; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), a Node at the Chemical Biology Consortium Sweden, Science for Life Laboratory, Department of Pharmacy, BMC , Uppsala University , Box 580, SE-751 23 Uppsala , Sweden., Poongavanam V; Department of Chemistry - BMC , Uppsala University , Box 576, SE-751 23 Uppsala , Sweden., Over B; Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit , AstraZeneca R&D Gothenburg , SE-431 83 Mölndal , Sweden., Ermondi G; Department of Molecular Biotechnology and Health Sciences , University of Torino , Quarello 15 , 10135 Torino , Italy., Caron G; Department of Molecular Biotechnology and Health Sciences , University of Torino , Quarello 15 , 10135 Torino , Italy., Matsson P; Department of Pharmacy, BMC , Uppsala University , Box 580, SE-751 23 Uppsala , Sweden., Kihlberg J; Department of Chemistry - BMC , Uppsala University , Box 576, SE-751 23 Uppsala , Sweden.
Source: Journal of medicinal chemistry [J Med Chem] 2018 May 10; Vol. 61 (9), pp. 4189-4202. Date of Electronic Publication: 2018 Apr 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.8b00347