The S230R Integrase Substitution Associated With Virus Load Rebound During Dolutegravir Monotherapy Confers Low-Level Resistance to Integrase Strand-Transfer Inhibitors.

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Title:	The S230R Integrase Substitution Associated With Virus Load Rebound During Dolutegravir Monotherapy Confers Low-Level Resistance to Integrase Strand-Transfer Inhibitors.
Authors:	Pham HT; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.; Department of Microbiology and Immunology, McGill University, Montreal, Canada., Labrie L; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.; Department of Microbiology and Immunology, McGill University, Montreal, Canada., Wijting IEA; Department of Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, Netherlands., Hassounah S; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, Canada., Lok KY; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada., Portna I; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.; Department of Microbiology and Immunology, McGill University, Montreal, Canada., Goring ME; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, Canada., Han Y; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada., Lungu C; Department of Viroscience, Erasmus University, Rotterdam, Netherlands., van der Ende ME; Department of Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, Netherlands., Brenner BG; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.; Faculty of Surgery, McGill University, Montreal, Canada., Boucher CA; Department of Viroscience, Erasmus University, Rotterdam, Netherlands., Rijnders BJA; Department of Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, Netherlands., van Kampen JJA; Department of Viroscience, Erasmus University, Rotterdam, Netherlands., Mesplède T; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.; Department of Microbiology and Immunology, McGill University, Montreal, Canada.; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, Canada., Wainberg MA; McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.; Department of Microbiology and Immunology, McGill University, Montreal, Canada.; Division of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, Canada.
Source:	The Journal of infectious diseases [J Infect Dis] 2018 Jul 24; Vol. 218 (5), pp. 698-706.
Publication Type:	Journal Article; Research Support, Non-U.S. Gov't
Journal Info:	Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
Database:	MEDLINE Ultimate

Description
ISSN:	1537-6613
DOI:	10.1093/infdis/jiy175