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Drug-Induced Alterations of Mitochondrial DNA Homeostasis in Steatotic and Nonsteatotic HepaRG Cells.

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Title: Drug-Induced Alterations of Mitochondrial DNA Homeostasis in Steatotic and Nonsteatotic HepaRG Cells.
Authors: Le Guillou D; INSERM, INRA, Université de Rennes, UBL, Nutrition Metabolisms and Cancer (NuMeCan), Rennes, France (D.L.G., S.B., K.B., B.F.); Sanofi, Investigative Toxicology, Alfortville, France (D.H., G.L.); and INSERM, UMR 1016, Institut Cochin, Université Paris V René Descartes, Paris, France (A.L.)., Bucher S; INSERM, INRA, Université de Rennes, UBL, Nutrition Metabolisms and Cancer (NuMeCan), Rennes, France (D.L.G., S.B., K.B., B.F.); Sanofi, Investigative Toxicology, Alfortville, France (D.H., G.L.); and INSERM, UMR 1016, Institut Cochin, Université Paris V René Descartes, Paris, France (A.L.)., Begriche K; INSERM, INRA, Université de Rennes, UBL, Nutrition Metabolisms and Cancer (NuMeCan), Rennes, France (D.L.G., S.B., K.B., B.F.); Sanofi, Investigative Toxicology, Alfortville, France (D.H., G.L.); and INSERM, UMR 1016, Institut Cochin, Université Paris V René Descartes, Paris, France (A.L.)., Hoët D; INSERM, INRA, Université de Rennes, UBL, Nutrition Metabolisms and Cancer (NuMeCan), Rennes, France (D.L.G., S.B., K.B., B.F.); Sanofi, Investigative Toxicology, Alfortville, France (D.H., G.L.); and INSERM, UMR 1016, Institut Cochin, Université Paris V René Descartes, Paris, France (A.L.)., Lombès A; INSERM, INRA, Université de Rennes, UBL, Nutrition Metabolisms and Cancer (NuMeCan), Rennes, France (D.L.G., S.B., K.B., B.F.); Sanofi, Investigative Toxicology, Alfortville, France (D.H., G.L.); and INSERM, UMR 1016, Institut Cochin, Université Paris V René Descartes, Paris, France (A.L.)., Labbe G; INSERM, INRA, Université de Rennes, UBL, Nutrition Metabolisms and Cancer (NuMeCan), Rennes, France (D.L.G., S.B., K.B., B.F.); Sanofi, Investigative Toxicology, Alfortville, France (D.H., G.L.); and INSERM, UMR 1016, Institut Cochin, Université Paris V René Descartes, Paris, France (A.L.)., Fromenty B; INSERM, INRA, Université de Rennes, UBL, Nutrition Metabolisms and Cancer (NuMeCan), Rennes, France (D.L.G., S.B., K.B., B.F.); Sanofi, Investigative Toxicology, Alfortville, France (D.H., G.L.); and INSERM, UMR 1016, Institut Cochin, Université Paris V René Descartes, Paris, France (A.L.) bernard.fromenty@inserm.fr.
Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2018 Jun; Vol. 365 (3), pp. 711-726. Date of Electronic Publication: 2018 Apr 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1521-0103
DOI:10.1124/jpet.117.246751